Clinical Ultrafast Laser Surgery: Recent Advances and Future Directions

Ultrafast pulsed lasers can be used to achieve remarkable precision during surgical ablation. Through nonlinear interactions with tissue, ultrafast lasers can provide a largely non-thermal mechanism of ablation and a unique ability to create targeted damage within bulk tissue. These advantages have...

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Published inIEEE journal of selected topics in quantum electronics Vol. 20; no. 2; pp. 242 - 255
Main Authors Hoy, Christopher L., Ferhanoglu, Onur, Yildirim, Murat, Ki Hyun Kim, Karajanagi, Sandeep S., Chan, Ka Man Carmen, Kobler, James B., Zeitels, Steven M., Ben-Yakar, Adela
Format Journal Article
LanguageEnglish
Published New York IEEE 01.03.2014
The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
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Abstract Ultrafast pulsed lasers can be used to achieve remarkable precision during surgical ablation. Through nonlinear interactions with tissue, ultrafast lasers can provide a largely non-thermal mechanism of ablation and a unique ability to create targeted damage within bulk tissue. These advantages have made ultrafast lasers the ideal surgical tool for various novel applications in ophthalmology. Clinical adoption of ultrafast lasers in other surgical applications remains limited in part due to the lack of a means for fiber delivery of ultrafast laser pulses as a flexible, hand-held surgical endoscope. This review provides an overview of the recent advances in bringing this unique surgical tool into the clinic. We discuss fundamental mechanisms and limitations of ultrafast laser ablation, novel techniques for overcoming these limitations, the current state of clinical applications, and conclude with our recent efforts in developing fiber-coupled probes for flexible ultrafast laser surgery and imaging.
AbstractList Ultrafast pulsed lasers can be used to achieve remarkable precision during surgical ablation. Through nonlinear interactions with tissue, ultrafast lasers can provide a largely non-thermal mechanism of ablation and a unique ability to create targeted damage within bulk tissue. These advantages have made ultrafast lasers the ideal surgical tool for various novel applications in ophthalmology. Clinical adoption of ultrafast lasers in other surgical applications remains limited in part due to the lack of a means for fiber delivery of ultrafast laser pulses as a flexible, hand-held surgical endoscope. This review provides an overview of the recent advances in bringing this unique surgical tool into the clinic. We discuss fundamental mechanisms and limitations of ultrafast laser ablation, novel techniques for overcoming these limitations, the current state of clinical applications, and conclude with our recent efforts in developing fiber-coupled probes for flexible ultrafast laser surgery and imaging.
Author Ben-Yakar, Adela
Chan, Ka Man Carmen
Ki Hyun Kim
Zeitels, Steven M.
Kobler, James B.
Yildirim, Murat
Hoy, Christopher L.
Ferhanoglu, Onur
Karajanagi, Sandeep S.
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  surname: Hoy
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  email: c.lhoy@erasmusmc.nl
  organization: Dept. of Mech. Eng., Univ. of Texas at Austin, Austin, TX, USA
– sequence: 2
  givenname: Onur
  surname: Ferhanoglu
  fullname: Ferhanoglu, Onur
  email: oferhanoglu@utexas.edu
  organization: Dept. of Mech. Eng., Univ. of Texas at Austin, Austin, TX, USA
– sequence: 3
  givenname: Murat
  surname: Yildirim
  fullname: Yildirim, Murat
  email: yildirim@utexas.edu
  organization: Dept. of Mech. Eng., Univ. of Texas at Austin, Austin, TX, USA
– sequence: 4
  surname: Ki Hyun Kim
  fullname: Ki Hyun Kim
  email: kihyunkim@utexas.edu
  organization: Dept. of Mech. Eng., Univ. of Texas at Austin, Austin, TX, USA
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  givenname: Sandeep S.
  surname: Karajanagi
  fullname: Karajanagi, Sandeep S.
  email: skarajanagi@partners.org
  organization: Center for Laryngeal Surg. & Voice Rehabilitation, Massachusetts Gen. Hosp., Boston, MA, USA
– sequence: 6
  givenname: Ka Man Carmen
  surname: Chan
  fullname: Chan, Ka Man Carmen
  email: kaman@mit.edu
  organization: Center for Laryngeal Surg. & Voice Rehabilitation, Massachusetts Gen. Hosp., Boston, MA, USA
– sequence: 7
  givenname: James B.
  surname: Kobler
  fullname: Kobler, James B.
  email: James.Kobler@mgh.harvard.edu
  organization: Center for Laryngeal Surg. & Voice Rehabilitation, Massachusetts Gen. Hosp., Boston, MA, USA
– sequence: 8
  givenname: Steven M.
  surname: Zeitels
  fullname: Zeitels, Steven M.
  email: zeitels.steven@mgh.harvard.edu
  organization: Center for Laryngeal Surg. & Voice Rehabilitation, Massachusetts Gen. Hosp., Boston, MA, USA
– sequence: 9
  givenname: Adela
  surname: Ben-Yakar
  fullname: Ben-Yakar, Adela
  email: ben-yakar@mail.utexas.edu
  organization: Dept. of Mech. Eng., Univ. of Texas at Austin, Austin, TX, USA
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Snippet Ultrafast pulsed lasers can be used to achieve remarkable precision during surgical ablation. Through nonlinear interactions with tissue, ultrafast lasers can...
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SubjectTerms Ablation
biomedical optical imaging
Endoscopes
Free electron lasers
Laser ablation
Laser beam cutting
Laser surgery
Lasers
Medical equipment
nonlinear optics
Ophthalmology
Pulsed lasers
Quantum electronics
Surgery
Ultrafast lasers
Ultrafast optics
Title Clinical Ultrafast Laser Surgery: Recent Advances and Future Directions
URI https://ieeexplore.ieee.org/document/6683019
https://www.proquest.com/docview/1468836431
https://search.proquest.com/docview/1671567611
Volume 20
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