Pharmacokinetics of CYP2C9, CYP2C19, and CYP2D6 substrates in healthy Chinese and European subjects

• Published in: European journal of clinical pharmacology Vol. 74; no. 3; pp. 285 - 296
• Main Authors: Lu, Sijie, Nand, R. A., Yang, J. S., Chen, Gang, Gross, A. S.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2018; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; CYP2D6 protein; Cytochrome P450; Enzymes; Minority & ethnic groups; Pharmacokinetics; Pharmacokinetics and Disposition; Pharmacology/Toxicology; CYP2C9; Chinese; Interethnic difference; Pharmacokinetics; CYP2C19; CYP2D6

Purpose The aim of this analysis is to compare the pharmacokinetics of drug substrates in healthy Chinese and European subjects of aligned CYP2C9, CYP2C19, or CYP2D6 enzyme activity, providing further insight into drivers of interethnic differences in pharmacokinetics. Methods Following identificati...