Decreased circulating microRNA-223 level predicts high on-treatment platelet reactivity in patients with troponin-negative non-ST elevation acute coronary syndrome

• Published in: Journal of thrombosis and thrombolysis Vol. 38; no. 1; pp. 65 - 72
• Main Authors: Zhang, Ying-Ying, Zhou, Xin, Ji, Wen-Jie, Shi, Rui, Lu, Rui-Yi, Li, Jin-Long, Yang, Guo-Hong, Luo, Tao, Zhang, Jian-Qi, Zhao, Ji-Hong, Jiang, Tie-Min, Li, Yu-Ming
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.07.2014; Springer Nature B.V
• Subjects: Acute Coronary Syndrome - blood; Acute Coronary Syndrome - drug therapy; Acute Coronary Syndrome - genetics; Aged; Aspirin - administration & dosage; Biomarkers - blood; Blood Platelets - metabolism; Cardiology; Cytochrome P-450 CYP2C19 - blood; Cytochrome P-450 CYP2C19 - genetics; Female; Hematology; Humans; Male; Medicine; Medicine & Public Health; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; Platelet Aggregation Inhibitors - administration & dosage; Real-Time Polymerase Chain Reaction; Retrospective Studies; Ticlopidine - administration & dosage; Ticlopidine - analogs & derivatives; Troponin - genetics; Troponin - metabolism; Clopidogrel; High on-treatment platelet reactivity; Platelet function test; MicroRNAs; Vasodilator-stimulated phosphoprotein

To investigate the relationship between circulating microRNA 223 (miR-223) levels and clopidogrel responsiveness in patients with coronary heart disease. A total of 62 consecutive patients with troponin-negative non-ST elevation acute coronary syndrome (NSTE-ACS) scheduled for elective percutaneous...