The selenium-containing compound 3-((4-chlorophenyl)selanyl)-1-methyl-1H-indole reverses depressive-like behavior induced by acute restraint stress in mice: modulation of oxido-nitrosative stress and inflammatory pathway

• Published in: Psychopharmacology Vol. 236; no. 10; pp. 2867 - 2880
• Main Authors: Casaril, Angela Maria, Domingues, Micaela, Bampi, Suely Ribeiro, de Andrade Lourenço, Darling, Padilha, Nathalia Batista, Lenardão, Eder João, Sonego, Mariana, Seixas, Fabiana Kommling, Collares, Tiago, Nogueira, Cristina Wayne, Dantzer, Robert, Savegnago, Lucielli
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2019; Springer Nature B.V
• Subjects: Animals; Anti-inflammatory agents; Antioxidants; Antioxidants - pharmacology; Antioxidants - therapeutic use; Behavior; Biochemical tests; Biomedical and Life Sciences; Biomedicine; Brain-derived neurotrophic factor; Catalase; Corticosterone; Depression - drug therapy; Depression - metabolism; Depression - psychology; Dioxygenase; Glucocorticoids; Glycogen; Glycogen synthase kinase 3; Indoles; Indoles - chemistry; Indoles - pharmacology; Indoles - therapeutic use; Inflammation; Inflammation - drug therapy; Inflammation - psychology; Male; Mental depression; Mice; Mood; mRNA; Neurosciences; Nitric oxide; Nitric-oxide synthase; Nitrosative Stress - drug effects; Nitrosative Stress - physiology; Original Investigation; Oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - physiology; Pharmacology/Toxicology; Plasma levels; Prefrontal cortex; Psychiatry; Random Allocation; Restraint, Physical - methods; Restraint, Physical - psychology; Selenium; Selenium Compounds - chemistry; Selenium Compounds - pharmacology; Selenium Compounds - therapeutic use; Signal Transduction - drug effects; Signal Transduction - physiology; Stress, Psychological - drug therapy; Stress, Psychological - metabolism; Stress, Psychological - psychology; Superoxide dismutase; Antidepressant; Oxidative stress; Neuroinflammation; Acute restraint stress; Selenium

Rationale and objectives Stress-induced alterations in oxidative and inflammatory parameters have been implicated in the pathophysiology of mood disorders. Based on the antioxidant and anti-inflammatory properties of the selenium-containing compound 3-((4-chlorophenyl)selanyl)-1-methyl-1 H -indole (...