Langerhans cell histiocytosis of mediastinal node

The predominant clinical and radiological features of Langerhans Cell Histiocytosis (LCH) in children are due to osseous involvement. Extra-osseous disease is far less common, occurring in association with bone disease or in isolation. In the present study, LCH was presumptively diagnosed on Ultraso...

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Published inIndian journal of pediatrics Vol. 75; no. 3; pp. 294 - 296
Main Authors Khadilkar, Urmila N., Rao, A. T. K., Sahoo, Kausalya Kumari, Pai, Mukta R.
Format Journal Article
LanguageEnglish
Published India Springer-Verlag 01.03.2008
Springer
Subjects
Biological and medical sciences
Biopsy, Needle
Clinical Brief
Diagnosis, Differential
General aspects
Gynecology
Hematologic and hematopoietic diseases
Histiocytosis, Langerhans-Cell - diagnosis
Histiocytosis, Langerhans-Cell - pathology
Humans
Infant
Lymph Nodes - pathology
Male
Mediastinum - pathology
Medical sciences
Medicine
Medicine & Public Health
Other diseases. Hematologic involvement in other diseases
Pediatrics
LCH
Lymph node
Mediastinum
Pediatrics
Langerhans cell histiocytosis
Node
Tropical medicine
Hemopathy
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Summary:The predominant clinical and radiological features of Langerhans Cell Histiocytosis (LCH) in children are due to osseous involvement. Extra-osseous disease is far less common, occurring in association with bone disease or in isolation. In the present study, LCH was presumptively diagnosed on Ultrasound guided Fine needle aspiration cytology (FNAC) of the mediastinal lymph node in a 18 month-old child. The diagnosis was confirmed by histological examination of the biopsy material. S-100 protein localization in the LCH cells is often positive on immunohistochemistry.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0019-5456
0973-7693
DOI:10.1007/s12098-008-0064-z