Global DNA 5hmC and CK195hmC+ Contents: A Promising Biomarker for Predicting Prognosis in Small Hepatocellular Carcinoma

• Published in: Current oncology (Toronto) Vol. 28; no. 5; pp. 3758 - 3770
• Main Authors: Jiang, Jinhua, Yan, Tinghua, Guo, Fang
• Format: Journal Article
• Language: English
• Published: MDPI 28.09.2021; MDPI AG
• Subjects: 5hmC; CK19; DNA methylation; prognosis; small hepatocellular carcinoma

Background: 5-Hydroxymethylcytosine (5hmC) with dynamic existence possesses multiple regulatory functions. Whereas, 5hmC’s impact on small hepatocellular carcinoma (SHCC) remains unclear. The present work focused on characterizing 5hmC content within SHCC and assessing the possibility of using globa...