Down-regulation of Long Noncoding RNA MALAT1 Protects Hippocampal Neurons Against Excessive Autophagy and Apoptosis via the PI3K/Akt Signaling Pathway in Rats with Epilepsy

• Published in: Journal of molecular neuroscience Vol. 65; no. 2; pp. 234 - 245
• Main Authors: Wu, Qiang, Yi, Xuewei
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2018; Springer Nature B.V
• Subjects: 1-Phosphatidylinositol 3-kinase; Adenocarcinoma; AKT protein; Apoptosis; Autophagy; Biomedical and Life Sciences; Biomedicine; Brain; Cell Biology; Epilepsy; Fluorescence; Fluorescence in situ hybridization; Hippocampus; Lung cancer; Lungs; Metastases; miRNA; Neurochemistry; Neurology; Neurons; Neurosciences; Phagocytosis; Polymerase chain reaction; Proteins; Proteomics; Rats; Reverse transcription; Ribonucleic acid; RNA; Rodents; Seizures; Signal transduction; Signaling; siRNA; Western blotting; MALAT1; Hippocampal neuron; Long noncoding RNA; PI3K/Akt signaling pathway; Epilepsy

Epilepsy is a common chronic brain disorder and is characterized by an enduring predisposition to generate seizures. The hippocampus is especially vulnerable to seizure-induced damage. In this study, we explore the ability of long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma tran...