Changes in Gastrointestinal Hormone Responses, Insulin Sensitivity, and Beta-Cell Function Within 2 Weeks After Gastric Bypass in Non-diabetic Subjects

• Published in: Obesity surgery Vol. 22; no. 7; pp. 1084 - 1096
• Main Authors: Jacobsen, S. H., Olesen, S. C., Dirksen, C., Jørgensen, N. B., Bojsen-Møller, K. N., Kielgast, U., Worm, D., Almdal, T., Naver, L. S., Hvolris, L. E., Rehfeld, J. F., Wulff, B. S., Clausen, T. R., Hansen, D. L., Holst, J. J., Madsbad, S.
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.07.2012; Springer Nature B.V
• Subjects: Adult; Appetite; C-Peptide - blood; Cholecystokinin - blood; Clinical Research; Confounding Factors (Epidemiology); Female; Gastric Bypass; Gastric Inhibitory Polypeptide - blood; Gastrins - blood; Gastrointestinal Hormones - blood; Gastrointestinal Hormones - metabolism; Gastrointestinal surgery; Ghrelin - blood; Glucagon - blood; Glucagon-Like Peptide 1 - blood; Glucagon-Like Peptide 2 - blood; Glucose; Glucose Tolerance Test; Hormones; Humans; Insulin - blood; Insulin - metabolism; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells - metabolism; Islet Amyloid Polypeptide - blood; Leptin - blood; Male; Medicine; Medicine & Public Health; Metabolism; Middle Aged; Obesity; Obesity, Morbid - blood; Obesity, Morbid - metabolism; Obesity, Morbid - surgery; Pancreatic Polypeptide - blood; Peptide YY - blood; Postprandial Period; Somatostatin - blood; Surgery; Time Factors; Weight Loss; Incretins; Obesity; Insulin resistance; Gastrointestinal hormones; Appetite-regulating hormone; Gastric bypass

Background Roux-en-Y gastric bypass (RYGB) surgery causes profound changes in secretion of gastrointestinal hormones and glucose metabolism. We present a detailed analysis of the early hormone changes after RYGB in response to three different oral test meals designed to provide this information with...