Surface deformation and shear flow in ligand mediated cell adhesion

• Published in: Journal of mathematical biology Vol. 73; no. 4; pp. 1035 - 1052
• Main Authors: Sircar, Sarthok, Roberts, Anthony J.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2016; Springer Nature B.V
• Subjects: Applications of Mathematics; Biophysical Phenomena; Cell Adhesion - physiology; Ligands; Mathematical and Computational Biology; Mathematics; Mathematics and Statistics; Models, Biological; Sticking probability; Binding kinetics; 92C05; Surface deformation; Adhesion; Micro hydrodynamics; Bistability

We present a unified, multiscale model to study the attachment/detachment dynamics of two deforming, charged, near spherical cells, coated with binding ligands and subject to a slow, homogeneous shear flow in a viscous, ionic fluid medium. The binding ligands on the surface of the cells experience b...