Molecular and Histological Identification of Bovine Papillomavirus 1, 2 and a Novel Genotype in Cutaneous Papillomas of Dairy Cattle in Taiwan

Bovine papillomaviruses (BPVs) are host‐specific and strongly epitheliotropic infectious agents that cause benign epithelial and mucosal proliferations, with potential for malignant transformation. However, BPV1, BPV2, and BPV5 are unique in their ability to infect both epithelial and connective tis...

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Published inTransboundary and emerging diseases Vol. 2025; no. 1; p. 5586786
Main Authors Chen, Guan-Shiun, Chiou, Hue-Ying, Chang, Yen-Chen, Liu, Hao-Ping, Pan, Yu-I, Chan, Ming-Yun, Liu, Tsung-Ching, Chia, Ming-Yuan, Huang, Chienjin, Chan, Jacky Peng-Wen, Chang, Chia-Yu
Format Journal Article
LanguageEnglish
Published Germany John Wiley & Sons, Inc 01.01.2025
Wiley
Subjects
Animals
Antigens
Biopsy
Bovine papillomavirus 1 - classification
Bovine papillomavirus 1 - genetics
Bovine papillomavirus 1 - isolation & purification
Cancer
Cattle
Cattle Diseases - epidemiology
Cattle Diseases - pathology
Cattle Diseases - virology
Connective tissue diseases
Connective tissues
Dairy cattle
Dairy farming
Dairy farms
Female
Genetic testing
Genomes
Genotype
Genotypes
Histopathology
Host specificity
Hybridization
Mesenchyme
Molecular biology
Papilloma
Papilloma - epidemiology
Papilloma - pathology
Papilloma - veterinary
Papilloma - virology
Papilloma viruses
Papillomavirus Infections - epidemiology
Papillomavirus Infections - pathology
Papillomavirus Infections - veterinary
Papillomavirus Infections - virology
Pathogenesis
Phylogeny
Skin
Skin Neoplasms - epidemiology
Skin Neoplasms - veterinary
Skin Neoplasms - virology
Taiwan - epidemiology
Tropism
Xipapillomavirus - classification
Xipapillomavirus - genetics
Xipapillomavirus - isolation & purification
Taiwan
United States > US
cattle
bovine papillomavirus (BPV)
Xipapillomavirus
fibropapilloma
in situ hybridization (ISH)
Online AccessGet full text

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Abstract Bovine papillomaviruses (BPVs) are host‐specific and strongly epitheliotropic infectious agents that cause benign epithelial and mucosal proliferations, with potential for malignant transformation. However, BPV1, BPV2, and BPV5 are unique in their ability to infect both epithelial and connective tissues. While BPV infections had been documented globally, there was no disease information reported from Taiwan. To investigate whether BPVs are associated with the development of cutaneous papillomas in dairy cattle in Taiwan, in the present study, eight cutaneous papilloma samples from six dairy farms were collected and analyzed by using histopathology, immunohistochemical (IHC) staining, and molecular biology methods. BPV1 and BPV2 were identified, along with a novel BPV sharing 80.9% sequence identity with BPV38. This novel BPV, classified under Xipapillomavirus , was detected in both epithelial and mesenchymal cells through in situ hybridization (ISH), suggesting a broader tissue tropism than typical Xipapillomavirus infections. These findings provide new insights into BPV diversity and pathogenesis.
AbstractList Bovine papillomaviruses (BPVs) are host-specific and strongly epitheliotropic infectious agents that cause benign epithelial and mucosal proliferations, with potential for malignant transformation. However, BPV1, BPV2, and BPV5 are unique in their ability to infect both epithelial and connective tissues. While BPV infections had been documented globally, there was no disease information reported from Taiwan. To investigate whether BPVs are associated with the development of cutaneous papillomas in dairy cattle in Taiwan, in the present study, eight cutaneous papilloma samples from six dairy farms were collected and analyzed by using histopathology, immunohistochemical (IHC) staining, and molecular biology methods. BPV1 and BPV2 were identified, along with a novel BPV sharing 80.9% sequence identity with BPV38. This novel BPV, classified under Xipapillomavirus, was detected in both epithelial and mesenchymal cells through in situ hybridization (ISH), suggesting a broader tissue tropism than typical Xipapillomavirus infections. These findings provide new insights into BPV diversity and pathogenesis.Bovine papillomaviruses (BPVs) are host-specific and strongly epitheliotropic infectious agents that cause benign epithelial and mucosal proliferations, with potential for malignant transformation. However, BPV1, BPV2, and BPV5 are unique in their ability to infect both epithelial and connective tissues. While BPV infections had been documented globally, there was no disease information reported from Taiwan. To investigate whether BPVs are associated with the development of cutaneous papillomas in dairy cattle in Taiwan, in the present study, eight cutaneous papilloma samples from six dairy farms were collected and analyzed by using histopathology, immunohistochemical (IHC) staining, and molecular biology methods. BPV1 and BPV2 were identified, along with a novel BPV sharing 80.9% sequence identity with BPV38. This novel BPV, classified under Xipapillomavirus, was detected in both epithelial and mesenchymal cells through in situ hybridization (ISH), suggesting a broader tissue tropism than typical Xipapillomavirus infections. These findings provide new insights into BPV diversity and pathogenesis.
Bovine papillomaviruses (BPVs) are host-specific and strongly epitheliotropic infectious agents that cause benign epithelial and mucosal proliferations, with potential for malignant transformation. However, BPV1, BPV2, and BPV5 are unique in their ability to infect both epithelial and connective tissues. While BPV infections had been documented globally, there was no disease information reported from Taiwan. To investigate whether BPVs are associated with the development of cutaneous papillomas in dairy cattle in Taiwan, in the present study, eight cutaneous papilloma samples from six dairy farms were collected and analyzed by using histopathology, immunohistochemical (IHC) staining, and molecular biology methods. BPV1 and BPV2 were identified, along with a novel BPV sharing 80.9% sequence identity with BPV38. This novel BPV, classified under , was detected in both epithelial and mesenchymal cells through in situ hybridization (ISH), suggesting a broader tissue tropism than typical infections. These findings provide new insights into BPV diversity and pathogenesis.
Bovine papillomaviruses (BPVs) are host‐specific and strongly epitheliotropic infectious agents that cause benign epithelial and mucosal proliferations, with potential for malignant transformation. However, BPV1, BPV2, and BPV5 are unique in their ability to infect both epithelial and connective tissues. While BPV infections had been documented globally, there was no disease information reported from Taiwan. To investigate whether BPVs are associated with the development of cutaneous papillomas in dairy cattle in Taiwan, in the present study, eight cutaneous papilloma samples from six dairy farms were collected and analyzed by using histopathology, immunohistochemical (IHC) staining, and molecular biology methods. BPV1 and BPV2 were identified, along with a novel BPV sharing 80.9% sequence identity with BPV38. This novel BPV, classified under Xipapillomavirus , was detected in both epithelial and mesenchymal cells through in situ hybridization (ISH), suggesting a broader tissue tropism than typical Xipapillomavirus infections. These findings provide new insights into BPV diversity and pathogenesis.
Bovine papillomaviruses (BPVs) are host-specific and strongly epitheliotropic infectious agents that cause benign epithelial and mucosal proliferations, with potential for malignant transformation. However, BPV1, BPV2, and BPV5 are unique in their ability to infect both epithelial and connective tissues. While BPV infections had been documented globally, there was no disease information reported from Taiwan. To investigate whether BPVs are associated with the development of cutaneous papillomas in dairy cattle in Taiwan, in the present study, eight cutaneous papilloma samples from six dairy farms were collected and analyzed by using histopathology, immunohistochemical (IHC) staining, and molecular biology methods. BPV1 and BPV2 were identified, along with a novel BPV sharing 80.9% sequence identity with BPV38. This novel BPV, classified under Xipapillomavirus , was detected in both epithelial and mesenchymal cells through in situ hybridization (ISH), suggesting a broader tissue tropism than typical Xipapillomavirus infections. These findings provide new insights into BPV diversity and pathogenesis.
Author Chen, Guan-Shiun
Chan, Jacky Peng-Wen
Liu, Tsung-Ching
Chiou, Hue-Ying
Liu, Hao-Ping
Chia, Ming-Yuan
Huang, Chienjin
Chan, Ming-Yun
Chang, Yen-Chen
Pan, Yu-I
Chang, Chia-Yu
AuthorAffiliation 7 Graduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung City 402, Taiwan
1 Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung City 402, Taiwan
6 Department of Animal Science and Biotechnology, Tunghai University, Taichung 407, Taiwan
4 Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
5 Veterinary Medical Teaching Hospital, Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
3 Graduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei 106, Taiwan
2 Graduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing University, Taichung City 402, Taiwan
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Copyright Copyright © 2025 Guan-Shiun Chen et al. Transboundary and Emerging Diseases published by John Wiley & Sons Ltd.
Copyright © 2025 Guan-Shiun Chen et al. Transboundary and Emerging Diseases published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (the “License”), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0
Copyright © 2025 Guan-Shiun Chen et al. Transboundary and Emerging Diseases published by John Wiley & Sons Ltd. 2025
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– notice: Copyright © 2025 Guan-Shiun Chen et al. Transboundary and Emerging Diseases published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (the “License”), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0
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Keywords cattle
bovine papillomavirus (BPV)
Xipapillomavirus
fibropapilloma
in situ hybridization (ISH)
Language English
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Snippet Bovine papillomaviruses (BPVs) are host‐specific and strongly epitheliotropic infectious agents that cause benign epithelial and mucosal proliferations, with...
Bovine papillomaviruses (BPVs) are host-specific and strongly epitheliotropic infectious agents that cause benign epithelial and mucosal proliferations, with...
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SubjectTerms Animals
Antigens
Biopsy
Bovine papillomavirus 1 - classification
Bovine papillomavirus 1 - genetics
Bovine papillomavirus 1 - isolation & purification
Cancer
Cattle
Cattle Diseases - epidemiology
Cattle Diseases - pathology
Cattle Diseases - virology
Connective tissue diseases
Connective tissues
Dairy cattle
Dairy farming
Dairy farms
Female
Genetic testing
Genomes
Genotype
Genotypes
Histopathology
Host specificity
Hybridization
Mesenchyme
Molecular biology
Papilloma
Papilloma - epidemiology
Papilloma - pathology
Papilloma - veterinary
Papilloma - virology
Papilloma viruses
Papillomavirus Infections - epidemiology
Papillomavirus Infections - pathology
Papillomavirus Infections - veterinary
Papillomavirus Infections - virology
Pathogenesis
Phylogeny
Skin
Skin Neoplasms - epidemiology
Skin Neoplasms - veterinary
Skin Neoplasms - virology
Taiwan - epidemiology
Tropism
Xipapillomavirus - classification
Xipapillomavirus - genetics
Xipapillomavirus - isolation & purification
Title Molecular and Histological Identification of Bovine Papillomavirus 1, 2 and a Novel Genotype in Cutaneous Papillomas of Dairy Cattle in Taiwan
URI https://www.ncbi.nlm.nih.gov/pubmed/40607128
https://www.proquest.com/docview/3227460533
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https://pubmed.ncbi.nlm.nih.gov/PMC12221544
Volume 2025
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