Changes in the position and volume of inactive X chromosomes during the G0/G1 transition

• Published in: Chromosome research Vol. 26; no. 3; pp. 179 - 189
• Main Authors: Lyu, Guoliang, Tan, Tan, Guan, Yiting, Sun, Lei, Liang, Qianjin, Tao, Wei
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.09.2018; Springer Nature B.V
• Subjects: Animal Genetics and Genomics; Animals; Biomedical and Life Sciences; Cell Biology; Cell cycle; Cell Line; Chromatin; Chromosomes; Chromosomes, Mammalian - metabolism; Epigenetics; Female; G1 phase; G1 Phase - physiology; Heterochromatin; Human Genetics; Life Sciences; Methylation; Mice; Nuclei; Nucleoli; Original Article; Plant Genetics and Genomics; Resting Phase, Cell Cycle - physiology; Transcription; X Chromosome - metabolism; X Chromosome Inactivation - physiology; X Chromosomes; trimethylated histone H3 on lysine 27 (H3K27me3); Xi movement; G0/G1 transition; dimethylated histone H3 on lysine 9 (H3K9me2); X chromosome inactivation

In female mammals, each cell silences one X chromosome by converting it into transcriptionally inert heterochromatin. The inactivation is concomitant with epigenetic changes including methylation of specific histone residues and incorporation of macroH2A. Such epigenetic changes may exert influence...