Absorption, distribution, metabolism, and excretion of [14C]-labeled naloxegol in healthy subjects

• Published in: International journal of clinical pharmacology and therapeutics Vol. 53; no. 10; p. 838
• Main Authors: Bui, Khanh, She, Fahua, Hutchison, Michael, Brunnström, Åsa, Sostek, Mark
• Format: Journal Article
• Language: English
• Published: Germany 01.10.2015
• Subjects: Aged; Carbon Radioisotopes; Humans; Male; Middle Aged; Morphinans - adverse effects; Morphinans - pharmacokinetics; Narcotic Antagonists - pharmacokinetics; Polyethylene Glycols - adverse effects; Polyethylene Glycols - pharmacokinetics; Tissue Distribution

To characterize the absorption, distribution, metabolism, and excretion of naloxegol, a PEGylated derivative of the µ-opioid antagonist naloxone, in healthy male subjects. [14C]-Labeled naloxegol (27 mg, 3.43 MBq) was administered as an oral solution to 6 fasted subjects. Blood, fecal, and urine sam...