Consecutive Prostate-Specific Membrane Antigen (PSMA) and Antigen Receptor (AR) PET Imaging Shows Positive Correlation with AR and PSMA Protein Expression in Primary Hormone-Naïve Prostate Cancer

• Published in: Journal of Nuclear Medicine Vol. 64; no. 6; pp. 863 - 868
• Main Authors: al Jalali, Valentin, Wasinger, Gabriel, Rasul, Sazan, Grubmüller, Bernhard, Wulkersdorfer, Beatrix, Balber, Theresa, Mitterhauser, Markus, Simon, Judit, Hacker, Marcus, Shariat, Shahrokh, Egger, Gerda, Zeitlinger, Markus
• Format: Journal Article
• Language: English
• Published: United States Society of Nuclear Medicine 01.06.2023
• Subjects: Androgen receptors; Antigens; Dihydrotestosterone; Edetic Acid - metabolism; Ethylenediamine; Fluorine isotopes; Gallium Radioisotopes; Humans; Magnetic resonance imaging; Male; Medical imaging; Membranes; Optical density; Patients; Positron emission; Positron emission tomography; Positron Emission Tomography Computed Tomography - methods; Positron-Emission Tomography - methods; Prospective Studies; Prostate - pathology; Prostate cancer; Prostate-Specific Antigen; Prostatectomy; Prostatic Neoplasms - pathology; Receptors; Staining; Treatment resistance; Tumors; [18F]FDHT PET; primary hormone-naïve prostate cancer; [68Ga]PSMA PET; AR protein expression; PSMA protein expression

The present study was carried out to investigate whether PET imaging can be used as a potential substitute for immunohistochemical analysis of tumor samples in prostate cancer (PC) patients. Correlation between imaging signals of 2 PET tracers and the corresponding target structures was assessed. Th...