Management of Cognitive Determinants in Senile Dementia of Alzheimer’s Type: Therapeutic Potential of a Novel Polyherbal Drug Product

• Published in: Clinical drug investigation Vol. 34; no. 12; pp. 857 - 869
• Main Authors: Sadhu, Ananya, Upadhyay, Prabhat, Agrawal, Aruna, Ilango, Kaliappan, Karmakar, Dipankar, Singh, Gur Prit Inder, Dubey, Govind Prasad
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2014; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - diagnosis; Alzheimer Disease - drug therapy; Alzheimer Disease - psychology; Cognition Disorders - diagnosis; Cognition Disorders - drug therapy; Cognition Disorders - psychology; Disease Management; Double-Blind Method; Drug Combinations; Female; Follow-Up Studies; Humans; Indans - therapeutic use; Internal Medicine; Male; Medicine; Medicine & Public Health; Middle Aged; Nootropic Agents - therapeutic use; Original Research Article; Pharmacology/Toxicology; Pharmacotherapy; Piperidines - therapeutic use; Plant Components, Aerial; Plant Extracts - isolation & purification; Plant Extracts - therapeutic use; Plant Preparations - isolation & purification; Plant Preparations - therapeutic use; Diosgenin; Test Formulation; Homocysteine; Mini Mental State Examination; Word Recall

Background and Objective The enigmatic etiology of neurodegenerative diseases poses a challenge for the development of novel and efficient drugs. The objective of the present study was to evaluate the efficacy of a polyherbal (test) formulation on cognitive functions, inflammatory markers and oxidat...