ROSA26 mice carry a modifier of Min-induced mammary and intestinal tumor development

• Published in: Mammalian genome Vol. 11; no. 12; pp. 1058 - 1062
• Main Authors: Kohlhepp, R L, Hegge, L F, Nett, J E, Moser, A R
• Format: Journal Article
• Language: English
• Published: United States Springer-Verlag 01.12.2000; Springer Nature B.V
• Subjects: Animals; Base Sequence; DNA Primers; Ethylnitrosourea - toxicity; Female; Genes, APC; Genetic Predisposition to Disease; Intestinal Neoplasms - genetics; Male; Mammary Neoplasms, Experimental - chemically induced; Mammary Neoplasms, Experimental - genetics; Mammary Neoplasms, Experimental - pathology; Mice; Mice, Mutant Strains; Min gene; Rodents; Tumors

B6.129S7-Gtrosa26 (B6.R26) mice carry a LacZ-neoR insertion on Chromosome (Chr) 6, made by promoter trapping with 129 ES cells. Female C57BL/6J Apc ᴹⁱⁿ /+ (B6Min/+) mice are highly susceptible to intestinal tumors and to the induction of mammary tumors after treatment with ethylnitrosourea (ENU). Ho...