Effect of Adjunctive Simvastatin on Depressive Symptoms Among Adults With Treatment-Resistant Depression A Randomized Clinical Trial

• Published in: JAMA network open Vol. 6; no. 2; p. e230147
• Main Authors: Husain, M. Ishrat, Chaudhry, Imran B., Khoso, Ameer B., Kiran, Tayyeba, Khan, Nawaz, Ahmad, Farooq, Hodsoll, John, Husain, M. Omair, Naqvi, Haider A., Nizami, Asad T., Chaudhry, Nasim, Khan, Hazrat A., Minhas, Fareed, Meyer, Jeffrey H., Ansari, Moin A., Mulsant, Benoit H., Husain, Nusrat, Young, Allan H.
• Format: Journal Article
• Language: English
• Published: United States American Medical Association 01.02.2023
• Subjects: Adult; Antidepressive Agents - therapeutic use; C-Reactive Protein; Depression - drug therapy; Depressive Disorder, Major - diagnosis; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Lipids; Male; Online Only; Original Investigation; Psychiatry; Simvastatin

Immune-metabolic disturbances have been implicated in the pathophysiology of major depressive disorder and may be more prominent in individuals with treatment-resistant depression (TRD). Preliminary trials suggest that lipid-lowering agents, including statins, may be useful adjunctive treatments for...