Click chemistry inspired facile one-pot synthesis of mannosyl triazoles and their hemagglutination inhibitory properties: The effect of alkyl chain spacer length between the triazole and phthalimide moieties in the aglycone backbone

• Published in: Carbohydrate research Vol. 534; pp. 108965 - 108968
• Main Authors: Al-Mughaid, Hussein, Jaradat, Younis, Khazaaleh, Maha, Al-Taani, Ibrahim
• Format: Journal Article
• Language: English
• Published: London Elsevier 01.12.2023
• Subjects: Biochemistry & Molecular Biology; carbohydrates; Chemistry; Chemistry, Applied; Chemistry, Organic; hemagglutination; Life Sciences & Biomedicine; ligands; moieties; phthalimide; Physical Sciences; Science & Technology; synthesis; triazoles; IMPROVE; URINARY-TRACT-INFECTIONS; DESIGN; Phthalimide; Glycoconjugates; STRATEGY; ESCHERICHIA-COLI; IN-VITRO; CuAAC reaction; Carbohydrate; OPTIMIZATION; ANTAGONISTS; BACTERIAL LECTIN FIMH; GLYCOMIMETICS; FimH

An efficient one-pot synthesis of a new series of mannosyl triazoles has been achieved through CuAAC reaction where the alkyl chain spacer between the phthalimide moiety and the triazole ring in the aglycone backbone is varied from one methylene to six methylene units. The target compounds were eval...