Sequential Molecular Events of Functional Trade-Offs in 5-Hydroxyisourate Hydrolase Before and After Gene Duplication Led to the Evolution of Transthyretin During Chordate Diversification

• Published in: Journal of molecular evolution Vol. 86; no. 7; pp. 457 - 469
• Main Authors: Yamauchi, Kiyoshi, Kasai, Kentaro
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2018; Springer Nature B.V
• Subjects: Amino acids; Animal Genetics and Genomics; Binding; Biomedical and Life Sciences; Cell Biology; Dependence; Enzymatic activity; Enzyme activity; Enzymes; Evolution; Evolutionary Biology; Gene duplication; Hydrolase; Hydrolysis; Life Sciences; Metabolism; Microbiology; Original Article; Plant Genetics and Genomics; Plant Sciences; Proteins; Reproduction (copying); Thyroid; Thyroid gland; Tradeoffs; Transthyretin; Triiodothyronine; Trout; Uric acid; Thyroid hormone; Evolution; Functional trade-off; Hydroxyisourate hydrolases; Transthyretin

Transthyretin (TTR), a plasma thyroid hormone distributor protein (THDP), emerged from 5-hydroxyisourate hydrolase (HIUHase), an enzyme involved in urate metabolism, by gene duplication at a stage of chordate evolution. Comparison of amino acid sequences revealed the presence of two His-rich segment...