Sequential Molecular Events of Functional Trade-Offs in 5-Hydroxyisourate Hydrolase Before and After Gene Duplication Led to the Evolution of Transthyretin During Chordate Diversification

Transthyretin (TTR), a plasma thyroid hormone distributor protein (THDP), emerged from 5-hydroxyisourate hydrolase (HIUHase), an enzyme involved in urate metabolism, by gene duplication at a stage of chordate evolution. Comparison of amino acid sequences revealed the presence of two His-rich segment...

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Bibliographic Details
Published inJournal of molecular evolution Vol. 86; no. 7; pp. 457 - 469
Main Authors Yamauchi, Kiyoshi, Kasai, Kentaro
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2018
Springer Nature B.V
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