Enantioselective metabolism of phenylpyrazole insecticides by rat liver microsomal CYP3A1, CYP2E1 and CYP2D2

• Published in: Pesticide biochemistry and physiology Vol. 176; p. 104861
• Main Authors: Zhang, Zhaoxian, Wang, Zhiqiang, Li, Qing X., Hua, Rimao, Wu, Xiangwei
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.07.2021
• Subjects: Enantiomer transformation; enantiomers; enantioselectivity; Enantioselectivity metabolism; Enzyme activity; fipronil; human health; liver; liver microsomes; metabolism; metabolites; Molecular docking; Phenylpyrazole insecticide; rats; risk assessment; Enantiomer transformation; Enzyme activity; Phenylpyrazole insecticide; Molecular docking; Enantioselectivity metabolism

The stereoselective difference of chiral pesticide enantiomers is an important factor of risk evaluation and the subject has received wide attention. In the present work, enantioselective metabolism of chiral phenylpyrazole insecticides including fipronil, ethiprole and flufiprole in rat liver micro...