Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson’s disease patient fibroblasts - Korecka, Joanna A; Thomas, Ria; Christensen, Dan P; Hinrich, Anthony J; Ferrari, Eliza J; Levy, Simon A; Hastings, Michelle L; Hallett, Penelope J; Isacson, Ole (Human molecular genetics, 2019)
Keywords: Adult; Aged; Autophagosomes - drug effects; Autophagosomes - metabolism; Female; Fibroblasts - metabolism; Gene Expression Regulation; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - antagonists & inhibitors; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - metabolism; Male; Middle Aged; Mitochondria - drug effects; Mitochondria - metabolism; Mutation; Oligonucleotides, Antisense - pharmacology; Parkinson Disease - genetics; Parkinson Disease - metabolism