Anti-tumor Effects of Sorafenib Administered at Different Time Points in Combination with Transarterial Embolization in a Rabbit VX2 Liver Tumor Model

• Published in: Cardiovascular and interventional radiology Vol. 40; no. 11; pp. 1763 - 1768
• Main Authors: Tomozawa, Yuki, Nitta, Norihisa, Ohta, Shinichi, Watanabe, Shobu, Sonoda, Akinaga, Nitta-Seko, Ayumi, Tsuchiya, Keiko, Murata, Kiyoshi
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2017; Springer Nature B.V
• Subjects: Animals; Anticancer properties; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - pharmacology; Cardiology; Combined Modality Therapy; Disease Models, Animal; Drug Administration Schedule; Embolization; Embolization, Therapeutic - methods; Imaging; Inhibitor drugs; Laboratory Investigation; Liver; Liver cancer; Liver Neoplasms - drug therapy; Liver Neoplasms - therapy; Medicine; Medicine & Public Health; Niacinamide - administration & dosage; Niacinamide - analogs & derivatives; Niacinamide - pharmacology; Nuclear Medicine; Phenylurea Compounds - administration & dosage; Phenylurea Compounds - pharmacology; Rabbits; Radiology; Targeted cancer therapy; Transplantation; Ultrasound; Combination therapy; Sorafenib; Transarterial embolization

Objective To investigate the most suitable timing parameters when using sorafenib to enhance the anti-tumor effects of transarterial embolization (TAE) in a rabbit VX2 liver tumor model. Materials and Methods Twenty-five Japanese white rabbits were randomly assigned to five equal groups two weeks af...