Effects of quercetin loaded nanostructured lipid carriers on the paraquat-induced toxicity in human lymphocytes
Paraquat (PQ) as a herbicide and an environmental pollutant with increasing importance due to its toxicity to humans and animals. This study aimed to evaluate the protective and antioxidant activity of quercetin loaded Nanostructured Lipid Carriers (QNLC) against toxicity induced by PQ. Blood lympho...
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| Published in | Pesticide biochemistry and physiology Vol. 167; p. 104586 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Inc
01.07.2020
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Paraquat (PQ) as a herbicide and an environmental pollutant with increasing importance due to its toxicity to humans and animals. This study aimed to evaluate the protective and antioxidant activity of quercetin loaded Nanostructured Lipid Carriers (QNLC) against toxicity induced by PQ. Blood lymphocytes were prepared using Ficoll polysaccharide and subsequently by gradient centrifugation. The QNLC was prepared using an ultra-sonication method, which was characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM).
The viability, reactive oxygen species (ROS), lipid peroxidation (LPO), mitochondrial membrane potential (MMP), lysosome membrane integrity, Bax and Bcl2 gene expression were evaluated in human isolated lymphocytes.
The results showed spherical QNLCs with nano-size range (52.7 nm) and high drug encapsulation efficiency (98.5% -96%). The results also indicated that PQ induced cell death, as well as ROS production, decreased by QNLC in human lymphocytes. Also, QNLC meaningfully restored MMP reduction, lysosomal membrane destabilization, and lipid peroxidation and were capable of preventing PQ-treated change in Bax and Bcl2 gene expression. We report that QNLC, have a significantly higher capacity to prevent PQ-induced toxicity than Q itself. It is suggested that the QNLC is a promising antioxidant for drug delivery to be used as a therapeutic and prophylactic agent for PQ poisoning.
[Display omitted]
•Quercetin loaded NLC protect lymphocytes in paraquat toxicity.•Quercetin loaded NLC mitigate paraquat-medaited oxidative damage.•Paraquat-mediated mitochondrial toxicity reduced by quercetin loaded NLC. |
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| AbstractList | Paraquat (PQ) as a herbicide and an environmental pollutant with increasing importance due to its toxicity to humans and animals. This study aimed to evaluate the protective and antioxidant activity of quercetin loaded Nanostructured Lipid Carriers (QNLC) against toxicity induced by PQ. Blood lymphocytes were prepared using Ficoll polysaccharide and subsequently by gradient centrifugation. The QNLC was prepared using an ultra-sonication method, which was characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM).The viability, reactive oxygen species (ROS), lipid peroxidation (LPO), mitochondrial membrane potential (MMP), lysosome membrane integrity, Bax and Bcl2 gene expression were evaluated in human isolated lymphocytes.The results showed spherical QNLCs with nano-size range (52.7 nm) and high drug encapsulation efficiency (98.5% -96%). The results also indicated that PQ induced cell death, as well as ROS production, decreased by QNLC in human lymphocytes. Also, QNLC meaningfully restored MMP reduction, lysosomal membrane destabilization, and lipid peroxidation and were capable of preventing PQ-treated change in Bax and Bcl2 gene expression. We report that QNLC, have a significantly higher capacity to prevent PQ-induced toxicity than Q itself. It is suggested that the QNLC is a promising antioxidant for drug delivery to be used as a therapeutic and prophylactic agent for PQ poisoning. Paraquat (PQ) as a herbicide and an environmental pollutant with increasing importance due to its toxicity to humans and animals. This study aimed to evaluate the protective and antioxidant activity of quercetin loaded Nanostructured Lipid Carriers (QNLC) against toxicity induced by PQ. Blood lymphocytes were prepared using Ficoll polysaccharide and subsequently by gradient centrifugation. The QNLC was prepared using an ultra-sonication method, which was characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The viability, reactive oxygen species (ROS), lipid peroxidation (LPO), mitochondrial membrane potential (MMP), lysosome membrane integrity, Bax and Bcl2 gene expression were evaluated in human isolated lymphocytes. The results showed spherical QNLCs with nano-size range (52.7 nm) and high drug encapsulation efficiency (98.5% -96%). The results also indicated that PQ induced cell death, as well as ROS production, decreased by QNLC in human lymphocytes. Also, QNLC meaningfully restored MMP reduction, lysosomal membrane destabilization, and lipid peroxidation and were capable of preventing PQ-treated change in Bax and Bcl2 gene expression. We report that QNLC, have a significantly higher capacity to prevent PQ-induced toxicity than Q itself. It is suggested that the QNLC is a promising antioxidant for drug delivery to be used as a therapeutic and prophylactic agent for PQ poisoning. [Display omitted] •Quercetin loaded NLC protect lymphocytes in paraquat toxicity.•Quercetin loaded NLC mitigate paraquat-medaited oxidative damage.•Paraquat-mediated mitochondrial toxicity reduced by quercetin loaded NLC. Paraquat (PQ) as a herbicide and an environmental pollutant with increasing importance due to its toxicity to humans and animals. This study aimed to evaluate the protective and antioxidant activity of quercetin loaded Nanostructured Lipid Carriers (QNLC) against toxicity induced by PQ. Blood lymphocytes were prepared using Ficoll polysaccharide and subsequently by gradient centrifugation. The QNLC was prepared using an ultra-sonication method, which was characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The viability, reactive oxygen species (ROS), lipid peroxidation (LPO), mitochondrial membrane potential (MMP), lysosome membrane integrity, Bax and Bcl2 gene expression were evaluated in human isolated lymphocytes. The results showed spherical QNLCs with nano-size range (52.7 nm) and high drug encapsulation efficiency (98.5% -96%). The results also indicated that PQ induced cell death, as well as ROS production, decreased by QNLC in human lymphocytes. Also, QNLC meaningfully restored MMP reduction, lysosomal membrane destabilization, and lipid peroxidation and were capable of preventing PQ-treated change in Bax and Bcl2 gene expression. We report that QNLC, have a significantly higher capacity to prevent PQ-induced toxicity than Q itself. It is suggested that the QNLC is a promising antioxidant for drug delivery to be used as a therapeutic and prophylactic agent for PQ poisoning.Paraquat (PQ) as a herbicide and an environmental pollutant with increasing importance due to its toxicity to humans and animals. This study aimed to evaluate the protective and antioxidant activity of quercetin loaded Nanostructured Lipid Carriers (QNLC) against toxicity induced by PQ. Blood lymphocytes were prepared using Ficoll polysaccharide and subsequently by gradient centrifugation. The QNLC was prepared using an ultra-sonication method, which was characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The viability, reactive oxygen species (ROS), lipid peroxidation (LPO), mitochondrial membrane potential (MMP), lysosome membrane integrity, Bax and Bcl2 gene expression were evaluated in human isolated lymphocytes. The results showed spherical QNLCs with nano-size range (52.7 nm) and high drug encapsulation efficiency (98.5% -96%). The results also indicated that PQ induced cell death, as well as ROS production, decreased by QNLC in human lymphocytes. Also, QNLC meaningfully restored MMP reduction, lysosomal membrane destabilization, and lipid peroxidation and were capable of preventing PQ-treated change in Bax and Bcl2 gene expression. We report that QNLC, have a significantly higher capacity to prevent PQ-induced toxicity than Q itself. It is suggested that the QNLC is a promising antioxidant for drug delivery to be used as a therapeutic and prophylactic agent for PQ poisoning. |
| ArticleNumber | 104586 |
| Author | Eftekhari, Aziz Turksoy, Vugar Ali Ahmadian, Elham Kavetskyy, Taras Khosroushahi, Ahmad Yari Khalilov, Rovshan |
| Author_xml | – sequence: 1 givenname: Elham surname: Ahmadian fullname: Ahmadian, Elham organization: Kidney Research Center & Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 2 givenname: Aziz surname: Eftekhari fullname: Eftekhari, Aziz email: Eftekharia@tbzmed.ac.ir organization: Maragheh University of Medical Sciences Maragheh, Iran – sequence: 3 givenname: Taras surname: Kavetskyy fullname: Kavetskyy, Taras organization: Drohobych Ivan Franko State Pedagogical University, Drohobych, Ukraine – sequence: 4 givenname: Ahmad Yari surname: Khosroushahi fullname: Khosroushahi, Ahmad Yari organization: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran – sequence: 5 givenname: Vugar Ali surname: Turksoy fullname: Turksoy, Vugar Ali organization: Department of Public Health, Faculty of Medicine, Bozok University, Yozgat, Turkey – sequence: 6 givenname: Rovshan surname: Khalilov fullname: Khalilov, Rovshan organization: Department of Biophysics and Molecular Biology, Baku State University, Baku, Azerbaijan |
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| Keywords | Nanostructured lipid carriers Blood lymphocytes Environmental pollutant Herbicide Quercetin |
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| Snippet | Paraquat (PQ) as a herbicide and an environmental pollutant with increasing importance due to its toxicity to humans and animals. This study aimed to evaluate... |
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| SubjectTerms | antioxidant activity Blood lymphocytes cell death centrifugation drugs encapsulation Environmental pollutant ficoll gene expression Herbicide humans light scattering lipid peroxidation lipids lymphocytes lysosomes membrane potential mitochondrial membrane Nanostructured lipid carriers paraquat poisoning pollutants Quercetin reactive oxygen species therapeutics toxicity transmission electron microscopy viability |
| Title | Effects of quercetin loaded nanostructured lipid carriers on the paraquat-induced toxicity in human lymphocytes |
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