Early Brain Injury Associated with Systemic Inflammation After Subarachnoid Hemorrhage

• Published in: Neurocritical care Vol. 28; no. 2; pp. 203 - 211
• Main Authors: Savarraj, Jude, Parsha, Kaushik, Hergenroeder, Georgene, Ahn, Sungho, Chang, Tiffany R., Kim, Dong H., Choi, H. Alex
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2018; Springer Nature B.V
• Subjects: Adult; Aged; Aneurysms; Brain Injuries - blood; Brain Injuries - etiology; Brain research; Clinical outcomes; Critical Care Medicine; Cytokines; Cytokines - blood; Edema; Female; Hemorrhage; Humans; Inflammation; Inflammation - blood; Inflammation - etiology; Informatics; Intensive; Internal Medicine; Intracranial Aneurysm - complications; Ischemia; Male; Medicine; Medicine & Public Health; Middle Aged; Models, Statistical; Neurology; Original Article; Prospective Studies; Severity of Illness Index; Statistical methods; Stroke; Subarachnoid Hemorrhage - complications; Subarachnoid Hemorrhage - etiology; Traumatic brain injury; Tumor necrosis factor-TNF; United States > US; Texas; Network modeling; Inflammation; Early brain injury; Subarachnoid hemorrhage

Background Early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) is defined as brain injury occurring within 72 h of aneurysmal rupture. Although EBI is the most significant predictor of outcomes after aSAH, its underlying pathophysiology is not well understood. We hypothesize tha...