Inhibition of YAP with siRNA prevents cartilage degradation and ameliorates osteoarthritis development - Gong, Yong; Li, Song-Jian; Liu, Rui; Zhan, Jian-Feng; Tan, Chao; Fang, Yi-Fei; Chen, Yan; Yu, Bo (Journal of molecular medicine (Berlin, Germany), 2019)
Keywords: Adaptor Proteins, Signal Transducing - genetics; Animals; Apoptosis; Arthritis; Biomedical and Life Sciences; Biomedicine; Bone growth; Cartilage (articular); Cartilage diseases; Cartilage, Articular - metabolism; Cartilage, Articular - pathology; Cell Cycle Proteins - genetics; Cells, Cultured; Chondrocytes; Chondrocytes - metabolism; Chondrocytes - pathology; Computed tomography; Gene expression; Homeostasis; Human Genetics; Humans; Hypertrophy; IL-1β; Immunohistochemistry; Injection; Internal Medicine; Male; Mice, Inbred C57BL; Molecular Medicine; Original Article; Osteoarthritis; Osteoarthritis - genetics; Osteoarthritis - pathology; Osteoarthritis - therapy; Osteogenesis; RNA, Small Interfering - genetics; RNA, Small Interfering - therapeutic use; RNAi Therapeutics; Signal transduction; siRNA; Subchondral bone; Transcription Factors - genetics; Up-Regulation; Western blotting; Yes-associated protein; Cartilage; YAP siRNA; Osteoarthritis