Proton Magnetic Resonance Spectroscopy for the Early Diagnosis of Parkinson Disease in the Substantia Nigra and Globus Pallidus: A Meta-Analysis With Trial Sequential Analysis

This study aimed to investigate the metabolic changes in globus pallidus (GP) and substantia nigra (SN) during the early stage of Parkinson disease (PD) using magnetic resonance spectroscopy (MRS). PubMed, Embase, Web of Science, and Chinese National Knowledge Infrastructure were searched till Novem...

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Published inFrontiers in neurology Vol. 13; p. 838230
Main Authors Gu, Wenbin, He, Chen, Chen, Juping, Li, Junchen
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 16.06.2022
Subjects
globus pallidus
meta-analysis
Neurology
Parkinson disease
proton magnetic resonance spectroscopy
substantia nigra
trial sequential analysis
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ISSN1664-2295
1664-2295
DOI10.3389/fneur.2022.838230

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Summary:This study aimed to investigate the metabolic changes in globus pallidus (GP) and substantia nigra (SN) during the early stage of Parkinson disease (PD) using magnetic resonance spectroscopy (MRS). PubMed, Embase, Web of Science, and Chinese National Knowledge Infrastructure were searched till November 2018. Eligible trials comparing early metabolic changes in GP and SN in patients with PD vs. controls were included. The mean differences with 95% confidence intervals were estimated with either fixed- or random-effects models using Review Manager 5.3 software. Trial sequential analysis was performed using TSA 0.9.5.10 beta software. Finally, 16 studies were selected from the search. Overall, the N -acetyl aspartate-to-creatine ratio showed a significant difference between patients with early-stage PD and healthy controls. The overall heterogeneity was P < 0.00001, I 2 = 94% in GP and P = 0.0002, I 2 = 74% in SN. The results revealed that MRS could be a more sensitive imaging biomarker in the diagnosis of early-stage PD.
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Edited by: Antoine Hone-Blanchet, Massachusetts General Hospital and Harvard Medical School, United States
Reviewed by: Susan Criswell, Washington University in St. Louis, United States; Yingchun Zhang, The Second Affiliated Hospital of Soochow University, China
These authors share first authorship
This article was submitted to Dementia and Neurodegenerative Diseases, a section of the journal Frontiers in Neurology
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2022.838230