Radiosynthesis and First-In-Human PET/MRI Evaluation with Clinical-Grade [18F]FTC-146

• Published in: Molecular imaging and biology Vol. 19; no. 5; pp. 779 - 786
• Main Authors: Shen, Bin, Park, Jun Hyung, Hjørnevik, Trine, Cipriano, Peter W., Yoon, Daehyun, Gulaka, Praveen K., Holly, Dawn, Behera, Deepak, Avery, Bonnie A., Gambhir, Sanjiv S., McCurdy, Christopher R., Biswal, Sandip, Chin, Frederick T.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2017; Springer Nature B.V
• Subjects: Adult; Ambient temperature; Azepines - chemical synthesis; Azepines - chemistry; Azepines - pharmacokinetics; Benzothiazoles - chemical synthesis; Benzothiazoles - chemistry; Benzothiazoles - pharmacokinetics; Blood-brain barrier; Brain; Cortical bone; Ethanol; Evaluation; Female; Fluorides; Humans; Imaging; In vivo methods and tests; Lungs; Magnetic Resonance Imaging; Male; Medicine; Medicine & Public Health; Neuroimaging; Neurological diseases; NMR; Nuclear magnetic resonance; Organs; Pancreas; Positron emission; Positron emission tomography; Quality control; Radioactivity; Radiochemistry; Radioisotopes; Radiology; Receptors; Research Article; Selectivity; Sodium chloride; Spleen; Thyroid; Tissue Distribution; Tomography; Automated radiosynthesis; Clinical; sigma-1 receptor; [18F]FTC-146; PET/MRI; Radiopharmaceuticals

Purpose Sigma-1 receptors (S1Rs) play an important role in many neurological disorders. Simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) with S1R radioligands may provide valuable information for diagnosing and guiding treatment for these diseases. Our previously repo...