Effects of adolescent nicotine and SR 147778 (Surinabant) administration on food intake, somatic growth and metabolic parameters in rats

• Published in: Neuropharmacology Vol. 54; no. 1; pp. 194 - 205
• Main Authors: Lamota, Laura, Bermudez-Silva, Francisco Javier, Marco, Eva-María, Llorente, Ricardo, Gallego, Araceli, Rodríguez de Fonseca, Fernando, Viveros, María-Paz
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2008
• Subjects: Adolescence; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal - drug effects; Blood Glucose - drug effects; Body weight; Body Weight - drug effects; Cannabinoid; Cholesterol, HDL - metabolism; Disease Models, Animal; Eating - drug effects; Enzyme-Linked Immunosorbent Assay - methods; Female; Food intake; Hormones - blood; Lipid Metabolism - drug effects; Male; Metabolism; Nicotine; Nicotine - pharmacology; Piperidines - pharmacology; Pyrazoles - pharmacology; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 - antagonists & inhibitors; Sex Factors; Substance Withdrawal Syndrome - etiology; Substance Withdrawal Syndrome - metabolism; Substance Withdrawal Syndrome - physiopathology; Surinabant; Adolescence; Food intake; Surinabant; Body weight; Cannabinoid; Metabolism; Nicotine

Tobacco smoking and obesity are worldwide important health problems with a growing impact in adolescent and young adults. One of the consequences of nicotine withdrawal is an increase in body weight that can act as a risk factor to relapse. Experimental therapies with a cannabinoid receptor antagoni...