Evaluation and Calibration of In Silico Models of Thrombin Generation Using Experimental Data from Healthy and Haemophilic Subjects

• Published in: Bulletin of mathematical biology Vol. 80; no. 8; pp. 1989 - 2025
• Main Authors: Chelle, Pierre, Morin, Claire, Montmartin, Aurélie, Piot, Michèle, Cournil, Michel, Tardy-Poncet, Brigitte
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2018; Springer Nature B.V
• Subjects: Bleeding; Calibration; Cascade chemical reactions; Cell Biology; Computer simulation; Genetic algorithms; Life Sciences; Mathematical and Computational Biology; Mathematical models; Mathematics; Mathematics and Statistics; Organic chemistry; Original Article; Parameters; Patients; Predictions; Proteins; Reaction kinetics; Thrombin; Computational modelling. In vitro assay kinetics . Sensitivity analysis; 92C45; Coagulation dynamics

The coagulation cascade comprises numerous chemical reactions between many proteins, that finally lead to the formation of a clot to stop bleeding. Many numerical models have attempted to translate understanding of this cascade into mathematical equations that simulate the chain reactions. However,...