Diagnosis, prevention, and management of bleeding episodes in Philadelphia-negative myeloproliferative neoplasms: recommendations by the Hemostasis Working Party of the German Society of Hematology and Medical Oncology (DGHO) and the Society of Thrombosis and Hemostasis Research (GTH)

• Published in: Annals of Hematology Vol. 95; no. 5; pp. 707 - 718
• Main Authors: Appelmann, Iris, Kreher, Stephan, Parmentier, Stefani, Wolf, Hans-Heinrich, Bisping, Guido, Kirschner, Martin, Bergmann, Frauke, Schilling, Kristina, Brümmendorf, Tim H., Petrides, Petro E., Tiede, Andreas, Matzdorff, Axel, Griesshammer, Martin, Riess, Hanno, Koschmieder, Steffen
• Format: Journal Article Book Review
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2016; Springer Nature B.V
• Subjects: Anticoagulants - adverse effects; Anticoagulants - therapeutic use; Antineoplastic Agents - adverse effects; Antineoplastic Agents - therapeutic use; Blood Coagulation Factors - therapeutic use; Blood Loss, Surgical - prevention & control; Blood Transfusion; Blood Vessels - drug effects; Blood Vessels - pathology; Clinical Trials as Topic; Contraindications; Deamino Arginine Vasopressin - therapeutic use; Disease Management; Elective Surgical Procedures; Hematology; Hemorrhage - diagnosis; Hemorrhage - etiology; Hemorrhage - prevention & control; Hemorrhage - therapy; Hemostatic Techniques; Humans; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative - complications; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative - drug therapy; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative - genetics; Liver - physiopathology; Medicine; Medicine & Public Health; Multicenter Studies as Topic; Myeloproliferative Disorders - complications; Myeloproliferative Disorders - drug therapy; Myeloproliferative Disorders - genetics; Oncology; Platelet Aggregation Inhibitors - adverse effects; Platelet Aggregation Inhibitors - therapeutic use; Platelet Function Tests; Platelet Transfusion; Postoperative Hemorrhage - etiology; Postoperative Hemorrhage - prevention & control; Postoperative Hemorrhage - therapy; Review Article; Thrombophilia - drug therapy; Thrombophilia - etiology; Tranexamic Acid - therapeutic use; von Willebrand Diseases - etiology; von Willebrand Factor - analysis; Essential thrombocythemia; Myeloproliferative neoplasms; Polycythemia vera; MPN; Management; Review; Hemorrhage; Bleeding

Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPN) comprise a heterogeneous group of chronic hematologic malignancies. The quality of life, morbidity, and mortality of patients with MPN are primarily affected by disease-related symptoms, thromboembolic and hemorrhagic complications...