Melatonin receptors: distribution in mammalian brain and their respective putative functions

• Published in: Brain Structure and Function Vol. 222; no. 7; pp. 2921 - 2939
• Main Authors: Ng, Khuen Yen, Leong, Mun Kit, Liang, Huazheng, Paxinos, George
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2017; Springer Nature B.V
• Subjects: Alzheimer's disease; Anatomy; Animals; Anxiety; Biomedical and Life Sciences; Biomedicine; Brain; Brain - metabolism; Brain architecture; Cell Biology; Central nervous system; Cerebellum; Cerebral cortex; Circadian rhythm; Circadian rhythms; Dorsal raphe nucleus; G protein-coupled receptors; Habenula; Humans; Huntington's disease; Hypothalamus; Mammals; Mammals - anatomy & histology; Melatonin; Melatonin receptors; Mesencephalon; Movement disorders; Neurodegenerative diseases; Neurology; Neurosciences; Pain; Parkinson's disease; Periaqueductal gray area; Pineal gland; Pituitary; Receptors, Melatonin - physiology; Retina; Review; Sleep; Thalamic reticular nucleus; Nociception; Depression; Neurodegenerative disease; Circadian rhythm; Neurogenesis; Melatonin receptor

Melatonin, through its different receptors, has pleiotropic functions in mammalian brain. Melatonin is secreted mainly by the pineal gland and exerts its effects via receptor-mediated and non-receptor-mediated actions. With recent advancement in neuroanatomical mapping, we may now understand better...