Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trial

• Published in: Neurology Vol. 66; no. 3; p. 366
• Format: Journal Article
• Language: English
• Published: United States 14.02.2006
• Subjects: Accidental Falls; Anti-Dyskinesia Agents - administration & dosage; Anti-Dyskinesia Agents - adverse effects; Anti-Dyskinesia Agents - therapeutic use; Breast Neoplasms - chemically induced; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Huntington Disease - drug therapy; Psychomotor Agitation - etiology; Suicide; Tetrabenazine - administration & dosage; Tetrabenazine - adverse effects; Tetrabenazine - therapeutic use; Treatment Outcome

Tetrabenazine (TBZ) selectively depletes central monoamines by reversibly binding to the type 2 vesicular monoamine transporter. Open-label reports indicate TBZ is effective in treating chorea. To examine the safety, efficacy, and dose tolerability of TBZ for treating chorea in Huntington disease (H...