Exosomes Secreted by Adipose-Derived Stem Cells Contribute to Angiogenesis of Brain Microvascular Endothelial Cells Following Oxygen–Glucose Deprivation In Vitro Through MicroRNA-181b/TRPM7 Axis

• Published in: Journal of molecular neuroscience Vol. 65; no. 1; pp. 74 - 83
• Main Authors: Yang, Yujia, Cai, Yue, Zhang, Yuan, Liu, Juan, Xu, Zhiqiang
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2018; Springer Nature B.V
• Subjects: Angiogenesis; Biomedical and Life Sciences; Biomedicine; Brain; Cell Biology; Cerebral blood flow; Deprivation; Endothelial cells; Exosomes; Glucose; Hypoxia; Hypoxia-inducible factors; Ischemia; Metalloproteinase; MicroRNAs; Microvasculature; Migration; miRNA; mRNA; Network formation; Neurochemistry; Neurology; Neurosciences; Occlusion; Oxygen; Polymerase chain reaction; Protein expression; Proteins; Proteomics; Ribonucleic acid; RNA; Stem cells; Stroke; Tissue inhibitor of metalloproteinase 3; Transient receptor potential proteins; Angiogenesis; Brain microvascular endothelial cells; Adipose-derived stem cells; TRPM7; Exosomes; Oxygen–glucose deprivation; MicroRNA-181b

Adipose-derived stem cells (ADSCs) have been demonstrated to promote cerebral vascular remodeling processes after stroke. However, the exact molecular mechanism by which ADSCs exert protective roles in ischemic stroke is still poorly understood. In this study, we identified the role of exosomal micr...