Comprehensive single cell analysis of pandemic influenza A virus infection in the human airways uncovers cell-type specific host transcriptional signatures relevant for disease progression and pathogenesis

• Published in: Frontiers in immunology Vol. 13; p. 978824
• Main Authors: Kelly, Jenna N., Laloli, Laura, V’kovski, Philip, Holwerda, Melle, Portmann, Jasmine, Thiel, Volker, Dijkman, Ronald
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 04.10.2022
• Subjects: human airway epithelium; Immunology; influenza viruses; innate immunity; single cell analysis; virus-host interactions

The respiratory epithelium constitutes the first line of defense against invading respiratory pathogens, such as the 2009 pandemic strain of influenza A virus (IAV, H1N1pdm09), and plays a crucial role in the host antiviral response to infection. Despite its importance, however, it remains unknown h...