Overexpression of EphA2 correlates with epithelial–mesenchymal transition-related proteins in gastric cancer and their prognostic importance for postoperative patients

• Published in: Medical oncology (Northwood, London, England) Vol. 29; no. 4; pp. 2691 - 2700
• Main Authors: Hou, Futao, Yuan, Weijie, Huang, Jin, Qian, Liyuan, Chen, Zhikang, Ge, Jie, Wu, Shaobin, Chen, Jinxiang, Wang, Jixu, Chen, Zihua
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.12.2012; Springer Nature B.V
• Subjects: Adult; Aged; beta Catenin - analysis; Cadherins - analysis; Epithelial-Mesenchymal Transition; Female; Hematology; Humans; Internal Medicine; Lymphatic Metastasis; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Staging; Oncology; Original Paper; Pathology; Prognosis; Receptor, EphA2 - analysis; Receptor, EphA2 - physiology; Stomach Neoplasms - chemistry; Stomach Neoplasms - mortality; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Vimentin - analysis; Immunohistochemistry; Epithelial–mesenchymal transition; Prognosis; Gastric cancer; EphA2

The expression of EphA2 and three epithelial–mesenchymal transition-related proteins (E-cadherin, β-catenin and vimentin) was detected by immunohistochemistry in human gastric cancer and normal gastric mucosa. The expression of EphA2 and vimentin was significantly higher in gastric cancer tissues th...