Tumor necrosis factor-α stimulates human amelotin gene transcription in gingival epithelial cells

• Published in: Inflammation research Vol. 67; no. 4; pp. 351 - 361
• Main Authors: Yamazaki, Mizuho, Iwai, Yasunobu, Noda, Keisuke, Matsui, Sari, Kato, Ayako, Takai, Hideki, Nakayama, Yohei, Ogata, Yorimasa
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2018; Springer Nature B.V
• Subjects: 1-Phosphatidylinositol 3-kinase; Allergology; Ameloblasts; Assaying; Basal lamina; Biomedical and Life Sciences; Biomedicine; CCAAT/enhancer-binding protein; Chromatin; Dermatology; EBP1 protein; Electrophoretic mobility; Enamel; Epithelial cells; Epithelium; Gene expression; Gene regulation; Gingiva; Immunology; Immunoprecipitation; Inflammation; Kinases; Mutation; Necrosis; Neurology; NF-κB protein; Original Research Paper; Pharmacology/Toxicology; Protein kinase A; Protein-tyrosine kinase; Proteins; Rheumatology; Transcription factors; Transfection; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Tyrosine; Western blotting; YY1 protein; Junctional epithelium; Transcription; Inflammation; Tumor necrosis factor-α; Gene promoter; Amelotin; Gingival epithelial cells

Objective Amelotin (AMTN) is an enamel protein that is localized in the basal lamina of ameloblasts in their maturation stage and the internal basal lamina of junctional epithelium (JE) and it is suggested that AMTN could be involved in the dentogingival attachment. To elucidate the transcriptional...