Catalytic enantioselective addition of diethylzinc to aldehydes using aziridine based chiral ligands

The readily available ferrocenyl substituted aziridinylmethanol 1 (FAM- 1) was used as a chiral catalyst in the diethylzinc addition reaction to aromatic and aliphatic aldehydes to give secondary alcohols in high yields and up to 99% enantiomeric excess at room temperature. The catalyst can be recov...

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Bibliographic Details
Published inTetrahedron: asymmetry Vol. 18; no. 8; pp. 1013 - 1016
Main Authors Bulut, Adnan, Aslan, Ayhan, Izgü, Enver Çagrı, Dogan, Özdemir
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 16.05.2007
Elsevier
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Chemistry, Physical
Physical Sciences
Science & Technology
ALCOHOLS
BINOL
REAGENTS
ALKYLATION
ASYMMETRIC ADDITION
CARBONYL-COMPOUNDS
CONJUGATE ADDITION
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Summary:The readily available ferrocenyl substituted aziridinylmethanol 1 (FAM- 1) was used as a chiral catalyst in the diethylzinc addition reaction to aromatic and aliphatic aldehydes to give secondary alcohols in high yields and up to 99% enantiomeric excess at room temperature. The catalyst can be recovered and used without losing its activity.
ISSN:0957-4166
1362-511X
DOI:10.1016/j.tetasy.2007.04.013