Acute stress response to a cognitive task in patients with major depressive disorder: potential metabolic and proinflammatory biomarkers

• Published in: Metabolic brain disease Vol. 34; no. 2; pp. 621 - 629
• Main Authors: Druzhkova, Tatiana, Pochigaeva, Ksenia, Yakovlev, Aleksander, Kazimirova, Evdokia, Grishkina, Maria, Chepelev, Aleksey, Guekht, Alla, Gulyaeva, Natalia
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2019; Springer Nature B.V
• Subjects: Adrenocorticotropic hormone; Adult; Anxiety; Anxiety - physiopathology; Biochemistry; Biomarkers; Biomarkers - metabolism; Biomedical and Life Sciences; Biomedicine; Brain-derived neurotrophic factor; Cholesterol; Cognition - physiology; Cognitive ability; Cortisol; Cytokines; Cytokines - metabolism; Depressive Disorder, Major - psychology; Female; Glucose; Heart rate; Heart Rate - physiology; Hormones; Humans; Hypothalamic-pituitary-adrenal axis; Hypothalamo-Hypophyseal System - metabolism; Hypothalamus; IL-1β; Immune system; Inflammation; Interleukin 6; Laboratories; Male; Mental depression; Metabolic Diseases; Metabolic pathways; Metabolism; Middle Aged; Neurology; Neurosciences; Neurotrophic factors; Oncology; Original Article; Parameters; Patients; Pituitary; Pituitary-Adrenal System - metabolism; Psychological stress; Stress response; Stress, Psychological - physiopathology; Triglycerides; Tumor necrosis factor-α; Metabolism; Major depression; Stress; HPAA, inflammation; Autonomic regulation

Responses of the hypothalamic-pituitary-adrenal axis (HPAA), immune system and metabolic pathways are involved in adaptation to stress, while alterations in these responses have been implicated in the development of major depressive disorder (MDD). Multiple laboratory indices are known to react in r...