Age-based analysis of choroidal thickness and choroidal vessel diameter in primary open-angle glaucoma

• Published in: International ophthalmology Vol. 36; no. 2; pp. 171 - 177
• Main Authors: Toprak, Ibrahim, Yaylalı, Volkan, Yildirim, Cem
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.04.2016; Springer Nature B.V
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Blood Vessels - pathology; Case-Control Studies; Choroid - blood supply; Choroid - pathology; Female; Glaucoma; Glaucoma, Open-Angle - pathology; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Ophthalmology; Original Paper; Tomography, Optical Coherence - methods; Glaucoma; Vessel; Aging; Enhanced depth imaging; Choroid; Optical coherence tomography
• ISSN: 0165-5701; 1573-2630; 1573-2630
• DOI: 10.1007/s10792-015-0092-4

We aimed to assess choroidal thickness and vessel diameter in patients with primary open-angle glaucoma (POAG) using enhanced depth imaging (EDI) optical coherence tomography (OCT) with age-based analysis. Fifty-four patients with a confirmed diagnosis of POAG and 44 age–sex matched healthy subjects were included into the study. A masked physician performed measurements of largest choroidal vessel diameter and choroidal thicknesses (subfoveal, nasal, and temporal) using EDI OCT. Subgroup analyses were performed to compare choroidal measurements based on age (with a cut point of 70 years). The study cohort comprised 54 patients with POAG (mean age of 63.2 ± 8.8 years) and 44 healthy control subjects (mean age of 62.9 ± 8.5 years) ( P  = 0.870). We found no significant differences in terms of choroidal measurements ( P  > 0.05) between the glaucoma and control groups. However, in the glaucoma group, patients with an age ≥70 years had significantly thinner subfoveal and nasal choroid compared to those of the patients with <70 years of age ( P  = 0.017, 0.002 respectively). In the control group, choroidal thickness and vessel measurements showed no significant difference when the subjects were subgrouped according to the age cut point ( P  > 0.05). Choroidal thickness and vessel caliber seem not to differ between patients with POAG and healthy controls. However, an age ≥70 years might be associated with thinning in subfoveal and nasal choroid in patients with POAG. Further studies are needed to elucidate whether choroidal thinning is a cause or result in POAG.