Reducing dentine hypersensitivity with nano-hydroxyapatite toothpaste: a double-blind randomized controlled trial

• Published in: Clinical oral investigations Vol. 22; no. 1; pp. 313 - 320
• Main Authors: Vano, M., Derchi, G., Barone, A., Pinna, R., Usai, P., Covani, U
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2018; Springer Nature B.V
• Subjects: Clinical trials; Dentin; Dentistry; Double-blind studies; Fluoride treatments; Fluorides; Hydroxyapatite; Hypersensitivity; Medicine; Original Article; Statistical analysis; Teeth; Toothpaste; Dentine hypersensitivity; Desensitizing agents; Fluoride; Nano-hydroxyapatite
• ISSN: 1432-6981; 1436-3771; 1436-3771
• DOI: 10.1007/s00784-017-2113-3

Objectives The present randomized double-blind clinical trial aimed to compare the efficacy in reducing dentin hypersensitivity of a dentifrice formulation containing nano-hydroxyapatite with a fluoride dentifrice and a placebo. Methods and materials One hundred and five subjects were recruited to participate in the study. A computer-generated random table with blocking to one of the three study treatments was used in order to have 35 subjects per group: (1) nano-hydroxyapatite 2% gel toothpaste fluoride free; (2) fluoride gel toothpaste; (3) placebo. Groups 1, 2, and 3 were instructed to treat their teeth for 10 min twice a day with the provided toothpaste gel. The participant’s dentin hypersensitivity was evaluated at baseline and after 2 and 4 weeks using airblast and tactile tests. In addition, a subjective evaluation using a visual analogue scale was used. Results Significant lower values of cold air sensitivity and tactile sensitivity ( p  < 0.05) were found for the test group at 2 weeks and 4 weeks. In addition, statistically significant ( p  < 0.05) lower values of sensitivity were reported for group 1 compared to those for groups 2 and 3 at 2 and 4 weeks, respectively. The VAS scores were significantly lower ( p  < 0.05) in the test group at 2 and 4 weeks compared to those at baseline and in the control groups. Conclusion The application of nano-hydroxyapatite in gel toothpaste fluoride free is an effective desensitizing agent providing relief from symptoms after 2 and 4 weeks.