Dexmedetomidine reduces postoperative delirium after joint replacement in elderly patients with mild cognitive impairment

• Published in: Aging clinical and experimental research Vol. 28; no. 4; pp. 729 - 736
• Main Authors: Liu, Yongzhe, Ma, Li, Gao, Minglong, Guo, Wenzhi, Ma, Yaqun
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2016; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Arthroplasty, Replacement - adverse effects; Cognitive ability; Cognitive Dysfunction - complications; Delirium; Delirium - prevention & control; Dexmedetomidine - therapeutic use; Female; Geriatrics/Gerontology; Humans; Male; Medicine; Medicine & Public Health; Original Article; Postoperative Complications - prevention & control; Prospective Studies; Surgery; Delirium; Amnestic mild cognitive impairment; Surgery; Dexmedetomidine

Background and aims Postoperative delirium (POD) is a common and serious surgical complication among the elderly, especially in those with amnestic mild cognitive impairment (aMCI). Dexmedetomidine (DEX) is neuroprotective for delirium. In this study, we determined the effect of intravenously admini...