Ochratoxin A promotes chronic enteritis and early colorectal cancer progression by targeting Rinck signaling

• Published in: Phytomedicine (Stuttgart) Vol. 122; p. 155095
• Main Authors: Liu, Xin, Yan, Chunli, Chang, Chunxiao, Meng, Fansong, Shen, Wenjie, Wang, Song, Zhang, Yi
• Format: Journal Article
• Language: English
• Published: Elsevier GmbH 01.01.2024
• Subjects: aflatoxins; animal models; antioxidant activity; azoxymethane; chronic exposure; Colitis; colon; Colorectal cancer (CRC); colorectal neoplasms; cytokines; dextran sulfate; enteritis; epithelium; genetically modified organisms; genome; histology; humans; immune response; neoplasm progression; Ochratoxin A; Oxidative stress; phenotype; rabbits; reactive oxygen species; RINCK; rodents; sequence analysis; subchronic exposure; therapeutics; ubiquitin; ubiquitin-protein ligase; ubiquitination; viruses; Oxidative stress; RINCK; Colitis; Ochratoxin A; Colorectal cancer (CRC)

•Oral sub-chronic OTA treatment facilitates DSS-triggered colitis pathological phenotypes in rodent model.•RINCK expression is positively correlated with IBD and CRC severity in human patients and rodent model.•Intestinal epithelial cells-specific Rinck knockout retards OTA-DSS co-triggered colitis...