Effectiveness of Midodrine treatment in patients with recurrent vasovagal syncope not responding to non-pharmacological treatment (STAND-trial)

• Published in: Europace (London, England) Vol. 13; no. 11; pp. 1639 - 1647
• Main Authors: Romme, Jacobus J.C.M., van Dijk, Nynke, Go-Schön, Ingeborg K., Reitsma, Johannes B., Wieling, Wouter
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.11.2011
• Subjects: Adrenergic alpha-1 Receptor Agonists - adverse effects; Adrenergic alpha-1 Receptor Agonists - therapeutic use; Adult; Cross-Over Studies; Double-Blind Method; Exercise; Female; Fluid Therapy; Humans; Male; Middle Aged; Midodrine - adverse effects; Midodrine - therapeutic use; Outcome Assessment (Health Care); Quality of Life; Recurrence; Syncope, Vasovagal - drug therapy; Syncope, Vasovagal - epidemiology; Treatment Outcome; Treatment; Midodrine; Vasovagal syncope; Quality of life

Aims Initial treatment of vasovagal syncope (VVS) consists of advising adequate fluid and salt intake, regular exercise, and physical counterpressure manoeuvres. Despite this treatment, up to 30% of patients continue to experience regular episodes of VVS. We investigated whether additional Midodrine...