The Effect of Triptolide Combined With Crocin on Arthritis in Mice: From Side Effect Attenuation to Therapy

• Published in: Frontiers in pharmacology Vol. 13; p. 908227
• Main Authors: Yan, Min, Yan, Yinyin, Zhang, Zhenqiang, Wang, Guoqiang, Shi, Wenbo, Jiang, Mengyuan, Zhao, Junwei, Wu, Xiangxiang, Zeng, Huahui
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 23.06.2022
• Subjects: arthritis; compatibility; crocin; Pharmacology; toxicity; triptolide

Clinical use of triptolide (TP) is restricted due to severe toxicity. This study assessed the protective effect of crocin (CR) as a natural antioxidant against TP-induced toxicity in bovine collagen type II-induced arthritis (CIA) in mice. The mice in the CIA model group showed macroscopic signs of...