Anandamide and other N‐acylethanolamines in human tumors

Long‐chain N‐acylethanolamines (NAE), including the endocannabinoid, anandamide, accumulate in mammalian tissues under a variety of pathological conditions. They have also been shown to inhibit the growth of various cancer cell lines in vitro. Here, we report the presence, in widely differing amount...

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Bibliographic Details
Published inLipids Vol. 37; no. 9; pp. 907 - 912
Main Authors Schmid, Patricia C., Wold, Lester E., Krebsbach, Randy J., Berdyshev, Evgueni V., Schmid, Harald H. O.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer‐Verlag 01.09.2002
Springer Nature B.V
Subjects
Arachidonic Acids - analysis
Arachidonic Acids - metabolism
Cells
Endocannabinoids
Ethanolamines - analysis
Ethanolamines - metabolism
Humans
Neoplasms - chemistry
Neoplasms - metabolism
Polyunsaturated Alkamides
Tissue Extracts - chemistry
Tissue Extracts - metabolism
Tumor Cells, Cultured
Tumors
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Summary:Long‐chain N‐acylethanolamines (NAE), including the endocannabinoid, anandamide, accumulate in mammalian tissues under a variety of pathological conditions. They have also been shown to inhibit the growth of various cancer cell lines in vitro. Here, we report the presence, in widely differing amounts (3.88–254.46 pmol/μmol lipid P), of NAE and their precursor phospholipids in various human tumors and some adjacent unaffected tissue. Anandamide ranged from 1.5 to 48% of total NAE, and incubation of tissue homogenates suggested possible NAE biosynthesis by both the established transacylation‐phosphodiesterase pathway via N‐acyl PE and by direct N‐acylation of ethanolamine.
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ISSN:0024-4201
1558-9307
DOI:10.1007/s11745-002-0978-z