High-Throughput Assessment of Real-World Medication Effects on QT Interval Prolongation: Observational Study

• Published in: JMIR cardio Vol. 7; p. e41055
• Main Authors: Yuan, Neal, Oesterle, Adam, Botting, Patrick, Chugh, Sumeet, Albert, Christine, Ebinger, Joseph, Ouyang, David
• Format: Journal Article
• Language: English
• Published: Canada JMIR Publications 20.01.2023
• Subjects: Cardiovascular disease; Chronic obstructive pulmonary disease; Comorbidity; Coronary vessels; Demographics; Diabetes; Drug stores; Electrocardiography; Electronic health records; Heart failure; Heart rate; Hypertension; Hypothesis testing; Kidney diseases; Liver diseases; Long QT syndrome; Original Paper; Patients; Pharmacy; Vein & artery diseases; clinical data monitoring; accessibility; comorbidity interaction; ECG; electronic health records; monitoring; pharmacovigilance; EHR; medication monitoring; clinical data; demographic interaction; assessment; electrocardiogram; QT prolongation; drug toxicity; medication effects

Drug-induced prolongation of the corrected QT interval (QTc) increases the risk for Torsades de Pointes (TdP) and sudden cardiac death. Medication effects on the QTc have been studied in controlled settings but may not be well evaluated in real-world settings where medication effects may be modulate...