Novel Functional Renal PET Imaging With 18F-FDS in Human Subjects

• Published in: Clinical nuclear medicine Vol. 44; no. 5; p. 410
• Main Authors: Werner, Rudolf A, Ordonez, Alvaro A, Sanchez-Bautista, Julian, Marcus, Charles, Lapa, Constantin, Rowe, Steven P, Pomper, Martin G, Leal, Jeffrey P, Lodge, Martin A, Javadi, Mehrbod S, Jain, Sanjay K, Higuchi, Takahiro
• Format: Journal Article
• Language: English
• Published: United States 01.05.2019
• Subjects: Fluorodeoxyglucose F18 - analogs & derivatives; Healthy Volunteers; Humans; Kidney - diagnostic imaging; Positron-Emission Tomography - methods; Radiopharmaceuticals - chemistry; Radiopharmaceuticals - pharmacokinetics; Sorbitol - analogs & derivatives

The novel PET probe 2-deoxy-2-F-fluoro-D-sorbitol (F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in 2 human volunteers. F-FDS was produced by a simple 1-step reduction from F-FDG. On dynamic renal PET, the cortex was delineated and activity...