Novel Functional Renal PET Imaging With 18F-FDS in Human Subjects
The novel PET probe 2-deoxy-2-F-fluoro-D-sorbitol (F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in 2 human volunteers. F-FDS was produced by a simple 1-step reduction from F-FDG. On dynamic renal PET, the cortex was delineated and activity...
Saved in:
| Published in | Clinical nuclear medicine Vol. 44; no. 5; p. 410 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.05.2019
|
| Subjects | |
| Online Access | Get more information |
Cover
Loading…
| Abstract | The novel PET probe 2-deoxy-2-F-fluoro-D-sorbitol (F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in 2 human volunteers. F-FDS was produced by a simple 1-step reduction from F-FDG. On dynamic renal PET, the cortex was delineated and activity gradually transited in the parenchyma, followed by radiotracer excretion. No adverse effects were reported. Given the higher spatiotemporal resolution of PET relative to conventional scintigraphy, F-FDS PET offers a more thorough evaluation of human renal kinetics. Due to its simple production from F-FDG, F-FDS is virtually available at any PET facility with radiochemistry infrastructure. |
|---|---|
| AbstractList | The novel PET probe 2-deoxy-2-F-fluoro-D-sorbitol (F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in 2 human volunteers. F-FDS was produced by a simple 1-step reduction from F-FDG. On dynamic renal PET, the cortex was delineated and activity gradually transited in the parenchyma, followed by radiotracer excretion. No adverse effects were reported. Given the higher spatiotemporal resolution of PET relative to conventional scintigraphy, F-FDS PET offers a more thorough evaluation of human renal kinetics. Due to its simple production from F-FDG, F-FDS is virtually available at any PET facility with radiochemistry infrastructure. |
| Author | Sanchez-Bautista, Julian Leal, Jeffrey P Javadi, Mehrbod S Higuchi, Takahiro Rowe, Steven P Jain, Sanjay K Marcus, Charles Pomper, Martin G Ordonez, Alvaro A Lapa, Constantin Lodge, Martin A Werner, Rudolf A |
| Author_xml | – sequence: 1 givenname: Rudolf A surname: Werner fullname: Werner, Rudolf A – sequence: 2 givenname: Alvaro A surname: Ordonez fullname: Ordonez, Alvaro A – sequence: 3 givenname: Julian surname: Sanchez-Bautista fullname: Sanchez-Bautista, Julian – sequence: 4 givenname: Charles surname: Marcus fullname: Marcus, Charles – sequence: 5 givenname: Constantin surname: Lapa fullname: Lapa, Constantin organization: Department of Nuclear Medicine, and – sequence: 6 givenname: Steven P surname: Rowe fullname: Rowe, Steven P – sequence: 7 givenname: Martin G surname: Pomper fullname: Pomper, Martin G – sequence: 8 givenname: Jeffrey P surname: Leal fullname: Leal, Jeffrey P – sequence: 9 givenname: Martin A surname: Lodge fullname: Lodge, Martin A – sequence: 10 givenname: Mehrbod S surname: Javadi fullname: Javadi, Mehrbod S – sequence: 11 givenname: Sanjay K surname: Jain fullname: Jain, Sanjay K – sequence: 12 givenname: Takahiro surname: Higuchi fullname: Higuchi, Takahiro |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30762825$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNj1tLwzAYhoMo7qD_QCR_oDPfl-bQyzFXNygqO-DlSLJ0ZrTpWFvBfy-igu_F89w98I7IZWyiJ-QO2ARYph5WxXbC_g3TLL0gQxBcJgwxG5BR2x4ZAwkyvSYDzpREjWJIps_Nh69o3kfXhSaaiq78N1_nG7qszSHEA30L3TsFnSf545qGSBd9bSJd9_boXdfekKvSVK2__fWYbPP5ZrZIipen5WxaJI4rTBOvOZagnRHMeAtCWzDSOie51TLNFFPK6BLQei7QCQnWqVIoV2qnLYc9jsn9T_fU29rvd6dzqM35c_f3Bb8A_25KBQ |
| CitedBy_id | crossref_primary_10_1007_s12149_019_01398_x crossref_primary_10_1053_j_semnuclmed_2020_12_011 crossref_primary_10_3390_pharmaceutics13111752 crossref_primary_10_1053_j_semnuclmed_2023_04_003 crossref_primary_10_1016_j_nucmedbio_2019_12_005 crossref_primary_10_1007_s12039_021_01924_3 crossref_primary_10_1053_j_semnuclmed_2021_12_003 crossref_primary_10_1016_j_cpet_2020_03_013 crossref_primary_10_2967_jnumed_120_244939 crossref_primary_10_1053_j_semnuclmed_2021_12_006 crossref_primary_10_1007_s40336_021_00469_2 crossref_primary_10_1016_j_pharma_2024_04_004 crossref_primary_10_1177_0271678X241236755 crossref_primary_10_1515_ract_2023_0206 crossref_primary_10_21886_2308_6424_2021_9_4_13_20 crossref_primary_10_1038_s41596_021_00613_2 crossref_primary_10_2967_jnumed_119_239806 crossref_primary_10_1186_s41181_024_00279_7 crossref_primary_10_1002_jlcr_3835 crossref_primary_10_3769_radioisotopes_73_109 crossref_primary_10_1002_jlcr_3887 crossref_primary_10_1007_s00259_019_04359_8 crossref_primary_10_1016_j_ijmm_2023_151581 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM |
| DOI | 10.1097/RLU.0000000000002494 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1536-0229 |
| ExternalDocumentID | 30762825 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: R01 HL131829 |
| GroupedDBID | --- .-D .3C .GJ .Z2 0R~ 29B 4Q1 4Q2 4Q3 53G 5GY 5RE 5VS 6J9 71W 8L- AAAAV AAHPQ AAIQE AAMTA AARTV AASCR AAYEP ABASU ABBUW ABDIG ABHFT ABJNI ABPXF ABVCZ ABXVJ ABZAD ABZZY ACCJW ACDDN ACEWG ACGFO ACGFS ACILI ACNWC ACWDW ACWRI ACXJB ACXNZ ADFPA ADGGA ADHPY ADNKB AE3 AE6 AEETU AENEX AFBFQ AFDTB AFFNX AFUWQ AGINI AHQNM AHRYX AHVBC AINUH AJCLO AJIOK AJNWD AJNYG AJZMW AKCTQ ALKUP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AOQMC BQLVK BS7 C45 CGR CS3 CUY CVF DIWNM DU5 DUNZO E.X EBS ECM EEVPB EIF EJD EX3 F2K F2L F5P FCALG FL- GNXGY GQDEL H0~ HLJTE HZ~ IKREB IN~ JF9 JG8 JK3 JK8 K8S KD2 KMI L-C LMP N4W N9A NPM N~M O9- OAG OAH OCUKA ODA OL1 OLG OLV OLZ OPUJH ORVUJ OUVQU OVD OVDNE OWU OWV OWW OWX OWY OWZ OXXIT P-K P2P R58 RLZ S4R S4S T8P TEORI TSPGW V2I W3M WOQ WOW X3V X3W XXN XYM YFH YOC ZFV ZGI ZZMQN |
| ID | FETCH-LOGICAL-c3724-e832f18ca50aeb158b1a6bcc63b86497077a8f12be352c561bc7f57cf8c8b31d2 |
| IngestDate | Mon Jul 21 06:07:30 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c3724-e832f18ca50aeb158b1a6bcc63b86497077a8f12be352c561bc7f57cf8c8b31d2 |
| OpenAccessLink | https://doi.org/10.1097/rlu.0000000000002494 |
| PMID | 30762825 |
| ParticipantIDs | pubmed_primary_30762825 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-May |
| PublicationDateYYYYMMDD | 2019-05-01 |
| PublicationDate_xml | – month: 05 year: 2019 text: 2019-May |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Clinical nuclear medicine |
| PublicationTitleAlternate | Clin Nucl Med |
| PublicationYear | 2019 |
| SSID | ssj0016164 |
| Score | 2.3298209 |
| Snippet | The novel PET probe 2-deoxy-2-F-fluoro-D-sorbitol (F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in... |
| SourceID | pubmed |
| SourceType | Index Database |
| StartPage | 410 |
| SubjectTerms | Fluorodeoxyglucose F18 - analogs & derivatives Healthy Volunteers Humans Kidney - diagnostic imaging Positron-Emission Tomography - methods Radiopharmaceuticals - chemistry Radiopharmaceuticals - pharmacokinetics Sorbitol - analogs & derivatives |
| Title | Novel Functional Renal PET Imaging With 18F-FDS in Human Subjects |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/30762825 |
| Volume | 44 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELaWIiEuqAVaXq184IYMm41jO8ctsKKIBbTsCm7IT4G0ZNHyOMCf7zh2moiHSpuDFcVRlOT7Mpn57BkjtOmcdYZyQ7hwjtCso4mkXJLcmZS63Cpjvd7RP2YHI3p4kV20Ws_N7JJ7ta2f3swr-R9U4Rjg6rNk_wHZPxeFA7AP-EILCEP7IYyPJ492vNWDX1NU9AbWt6f7w61fN2H5oXOvsyaiR3p7Z17bCKI9mAuvv9w1XdPdKkey8CWO5fTVsPu5ncbsmMGDmYxdLYOeTM2kCFJ0d_wop5O66wxYdWWfyE8J7yG6qj4nuyZlHz61h7vG0H9TiPC5T9W0v21bGU8_oTkqGNG6huqOkUVZw1TSMJ31lQkPpYEHR6NQWjJuECXS5ukAxO1NCSsYKeYTcP_e-6KwdtU1g2YgxPBrpnqhJw5AMQgjq0zLnO-8dTvzaK66xIuYpPRNhp_RQgwqcDcw5Atq2WIRzfUjfkuoWxIF10TBJVEwEAVHomBPFByJgq8LXBIFV0RZRqPe_nD3gMS1M4hOeYcSC5baJcIveCHhd5wJlUimtGapEozmvM25FC7pKAseuAYnWmnuMq6d0EKliel8RZ8KoM4KwqllxuVtX7VIUiZyaZxLdUZTITLFWXsVfQsPf3kbCqRcVq9l7d2edTRfU2gDzTr4Iu13cO_u1Y8SiN9Ra0qU |
| linkProvider | National Library of Medicine |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Novel+Functional+Renal+PET+Imaging+With+18F-FDS+in+Human+Subjects&rft.jtitle=Clinical+nuclear+medicine&rft.au=Werner%2C+Rudolf+A&rft.au=Ordonez%2C+Alvaro+A&rft.au=Sanchez-Bautista%2C+Julian&rft.au=Marcus%2C+Charles&rft.date=2019-05-01&rft.eissn=1536-0229&rft.volume=44&rft.issue=5&rft.spage=410&rft_id=info:doi/10.1097%2FRLU.0000000000002494&rft_id=info%3Apmid%2F30762825&rft_id=info%3Apmid%2F30762825&rft.externalDocID=30762825 |