TMS and EEG Pharmacodynamic Effects of a Selective Sphingosine‐1‐Phosphate Subtype 1 Receptor Agonist on Cortical Excitability in Healthy Subjects

• Published in: Clinical pharmacology and therapeutics Vol. 117; no. 3; pp. 787 - 797
• Main Authors: Cuba, Catherine M. K. E., Goede, Annika A., Klaassen, Erica S., Otto, Marije E., Doll, Robert J., Kim, Jessica, Demitrack, Mark A., Chen, Ruihua, Groeneveld, Geert Jan, Heuberger, Jules A. A. C.
• Format: Journal Article
• Language: English
• Published: United States 01.03.2025
• Subjects: Adult; Anticonvulsants - pharmacology; Cortical Excitability - drug effects; Cross-Over Studies; Double-Blind Method; Electroencephalography - drug effects; Healthy Volunteers; Humans; Male; Middle Aged; Sphingosine-1-Phosphate Receptors; Transcranial Magnetic Stimulation - methods; Young Adult

Current anti‐epileptic drugs lack efficacy, cause many side effects and one third of all patients are treatment‐resistant. Drugs targeting the sphingosine‐1‐phosphate receptor show potential anti‐convulsant effects in animal models and decrease cortical excitability in patients with multiple scleros...