Genome-wide mapping of Piwi association with specific loci in Drosophila ovaries

• Published in: G3 : genes - genomes - genetics Vol. 11; no. 2
• Main Authors: Liu, Na, Neuenkirchen, Nils, Zhong, Mei, Lin, Haifan
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.02.2021
• Subjects: Animals; Argonaute Proteins - metabolism; Binding sites; DNA Transposable Elements; Drosophila - genetics; Drosophila melanogaster - genetics; Drosophila Proteins - genetics; Epigenesis, Genetic; Female; Genomes; Insects; Investigation; Ovaries; Ovary - metabolism; RNA, Small Interfering; DamID-seq; chromatin association; Piwi; piRNA

Small noncoding RNA pathways have been implicated in diverse mechanisms of gene regulation. In Drosophila ovaries, Piwi binds to Piwi-interacting RNAs (piRNAs) of mostly 24–28 nucleotides (nt) and plays an important role in germline stem cell maintenance, transposon repression, and epigenetic regula...