A critical analysis on the concentrations of phenolic compounds tested using in vitro and in vivo Parkinson's disease models

Phenolic compounds (PCs) have neuroprotective effects with potential to prevent or slower the progression of Parkinson's disease (PD). However, whether the PCs neuroprotective effects can be observed under their dietary concentrations remains unclear. Therefore, we searched for the most cited a...

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Published inCritical reviews in food science and nutrition Vol. 64; no. 19; pp. 6596 - 6615
Main Authors Perdigão, José Messias, Teixeira, Bruno José Brito, Carvalho-da-Silva, Vinicius, Prediger, Rui Daniel, Lima, Rafael Rodrigues, Rogez, Herve
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 25.07.2024
Taylor & Francis Ltd
Subjects
Animals
bioactive compounds
Bioavailability
Biological Availability
Design of experiments
Disease Models, Animal
Experimental design
Humans
In vivo methods and tests
Movement disorders
natural antioxidants
Neurodegenerative diseases
Neuroprotection
Neuroprotective Agents - pharmacokinetics
Neuroprotective Agents - pharmacology
Parkinson Disease - drug therapy
Parkinson's disease
Phenolic compounds
Phenols
Phenols - analysis
Phenols - pharmacokinetics
Phenols - pharmacology
bioactive compounds
Parkinson’s disease
natural antioxidants
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Abstract Phenolic compounds (PCs) have neuroprotective effects with potential to prevent or slower the progression of Parkinson's disease (PD). However, whether the PCs neuroprotective effects can be observed under their dietary concentrations remains unclear. Therefore, we searched for the most cited articles in density on PCs and PD in the Web of Science Core Collection and All-Database (WoS-CC/AD) and selected the articles based on our eligibility criteria. From these 81 articles selected, we extracted information on experimental design, compounds tested, concentration and/or dose administered, route of administration, and main results obtained. We compared the concentrations of PCs evaluated in vitro with the concentrations bioavailable in the human bloodstream. Further, after extrapolation to humans, we compared the doses administered to animals in vivo with the daily consumed amounts of PCs. Concentrations evaluated in 21 in vitro laboratory studies were higher than those bioavailable in the bloodstream. In the case of in vivo laboratory studies, only one study administered doses of PCs in normal daily amount. The results of the comparisons demonstrate that the neuroprotective effects of the selected articles are mainly associated with concentrations, amounts and routes of administration that do not correspond to the consumption of phenolic compounds through the diet.
AbstractList Phenolic compounds (PCs) have neuroprotective effects with potential to prevent or slower the progression of Parkinson's disease (PD). However, whether the PCs neuroprotective effects can be observed under their dietary concentrations remains unclear. Therefore, we searched for the most cited articles in density on PCs and PD in the Web of Science Core Collection and All-Database (WoS-CC/AD) and selected the articles based on our eligibility criteria. From these 81 articles selected, we extracted information on experimental design, compounds tested, concentration and/or dose administered, route of administration, and main results obtained. We compared the concentrations of PCs evaluated in vitro with the concentrations bioavailable in the human bloodstream. Further, after extrapolation to humans, we compared the doses administered to animals in vivo with the daily consumed amounts of PCs. Concentrations evaluated in 21 in vitro laboratory studies were higher than those bioavailable in the bloodstream. In the case of in vivo laboratory studies, only one study administered doses of PCs in normal daily amount. The results of the comparisons demonstrate that the neuroprotective effects of the selected articles are mainly associated with concentrations, amounts and routes of administration that do not correspond to the consumption of phenolic compounds through the diet.
Phenolic compounds (PCs) have neuroprotective effects with potential to prevent or slower the progression of Parkinson's disease (PD). However, whether the PCs neuroprotective effects can be observed under their dietary concentrations remains unclear. Therefore, we searched for the most cited articles in density on PCs and PD in the Web of Science Core Collection and All-Database (WoS-CC/AD) and selected the articles based on our eligibility criteria. From these 81 articles selected, we extracted information on experimental design, compounds tested, concentration and/or dose administered, route of administration, and main results obtained. We compared the concentrations of PCs evaluated in vitro with the concentrations bioavailable in the human bloodstream. Further, after extrapolation to humans, we compared the doses administered to animals in vivo with the daily consumed amounts of PCs. Concentrations evaluated in 21 in vitro laboratory studies were higher than those bioavailable in the bloodstream. In the case of in vivo laboratory studies, only one study administered doses of PCs in normal daily amount. The results of the comparisons demonstrate that the neuroprotective effects of the selected articles are mainly associated with concentrations, amounts and routes of administration that do not correspond to the consumption of phenolic compounds through the diet.Phenolic compounds (PCs) have neuroprotective effects with potential to prevent or slower the progression of Parkinson's disease (PD). However, whether the PCs neuroprotective effects can be observed under their dietary concentrations remains unclear. Therefore, we searched for the most cited articles in density on PCs and PD in the Web of Science Core Collection and All-Database (WoS-CC/AD) and selected the articles based on our eligibility criteria. From these 81 articles selected, we extracted information on experimental design, compounds tested, concentration and/or dose administered, route of administration, and main results obtained. We compared the concentrations of PCs evaluated in vitro with the concentrations bioavailable in the human bloodstream. Further, after extrapolation to humans, we compared the doses administered to animals in vivo with the daily consumed amounts of PCs. Concentrations evaluated in 21 in vitro laboratory studies were higher than those bioavailable in the bloodstream. In the case of in vivo laboratory studies, only one study administered doses of PCs in normal daily amount. The results of the comparisons demonstrate that the neuroprotective effects of the selected articles are mainly associated with concentrations, amounts and routes of administration that do not correspond to the consumption of phenolic compounds through the diet.
Author Carvalho-da-Silva, Vinicius
Prediger, Rui Daniel
Teixeira, Bruno José Brito
Lima, Rafael Rodrigues
Perdigão, José Messias
Rogez, Herve
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Issue 19
Keywords bioactive compounds
Parkinson’s disease
natural antioxidants
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Snippet Phenolic compounds (PCs) have neuroprotective effects with potential to prevent or slower the progression of Parkinson's disease (PD). However, whether the PCs...
Phenolic compounds (PCs) have neuroprotective effects with potential to prevent or slower the progression of Parkinson’s disease (PD). However, whether the PCs...
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SubjectTerms Animals
bioactive compounds
Bioavailability
Biological Availability
Design of experiments
Disease Models, Animal
Experimental design
Humans
In vivo methods and tests
Movement disorders
natural antioxidants
Neurodegenerative diseases
Neuroprotection
Neuroprotective Agents - pharmacokinetics
Neuroprotective Agents - pharmacology
Parkinson Disease - drug therapy
Parkinson's disease
Phenolic compounds
Phenols
Phenols - analysis
Phenols - pharmacokinetics
Phenols - pharmacology
Title A critical analysis on the concentrations of phenolic compounds tested using in vitro and in vivo Parkinson's disease models
URI https://www.tandfonline.com/doi/abs/10.1080/10408398.2023.2171960
https://www.ncbi.nlm.nih.gov/pubmed/36718558
https://www.proquest.com/docview/3074250269
https://www.proquest.com/docview/2771333082/abstract/
Volume 64
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